CD51 (ITGAV) Rat Monoclonal Antibody [Clone ID: AvB6 53a.2]

CAT#: TA352872L

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Rat monoclonal Anti-Integrin aVb6 Clone AvB6 53a.2


Product Datasheet for 'TA352872L'


USD 1,140.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Clone Name AvB6 53a.2
Recommend Dilution FACS ; IF ; Functional
Reactivity Human
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
Formulation PBS with 0.02% Sodium Azide
Concentration 1 mg/ml
Purification Purified by affinity chromatography.
Gene Name integrin subunit alpha V
Background Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
Synonyms CD51; MSK8; VNRA; VTNR
Note Recommended Concentration: 10ug/ml
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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