p38 (MAPK14) Rabbit Polyclonal Antibody

CAT#: TA321327

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Anti-MAPK14 (Phospho-Thr180) Rabbit Polyclonal Antibody


 Product Datasheet for 'TA321327'

USD 335.00


Availability*
3 Weeks

Size
    • 100 ul


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1:500-1000, IHC: 1:50-100
Reactivity Human, Mouse, Rat
Modifications Phospho-specific
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of threonine 180 (E-M-T(p)-G-Y ) derived from Human MAPK14.
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration 1 mg/ml
Purification Antigen affinity purification
Predicted Protein Size 43 kDa
Gene Name mitogen-activated protein kinase 14
Background Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
Synonyms CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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