p38(MAPK14) Rabbit Polyclonal Antibody
Anti-MAPK14 (Phospho-Thr180) Rabbit Polyclonal Antibody
Product Datasheet for 'TA321327'
|Recommend Dilution||WB: 1:500-1000, IHC: 1:50-100|
|Reactivity||Human; Mouse; Rat|
|Immunogen||Peptide sequence around phosphorylation site of threonine 180 (E-M-T(p)-G-Y ) derived from Human MAPK14.|
|Formulation||PBS pH7.3, 0.05% NaN3, 50% glycerol|
|Purification||Antigen affinity purification|
|Predicted Protein Size||43kDa|
|Gene Name||mitogen-activated protein kinase 14|
|Background||Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.|
|Protein Families||Protein Kinase, Druggable Genome|
|Protein Pathways||MAPK signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.