FIGF Rabbit Polyclonal Antibody

CAT#: TA319110

Rabbit polyclonal anti-VEGF-D antibody

Antibody Service


 Product Datasheet for 'TA319110'

USD 353


Availability*
2 Weeks

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB
Recommend Dilution WB: 0.5-4 ug/ml
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen E. coli expressed human VEGF-D
Isotype Rabbit IgG
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Concentration 0.5 mg/ml
Purification Affinity purified
Gene Name c-fos induced growth factor
Background EGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. The recombinant VEGF-D as the immunogen was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.
Synonyms VEGF-D|VEGFD
Reference Data
Protein Families Secreted Protein, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, mTOR signaling pathway, Focal adhesion, Pathways in cancer, Renal cell carcinoma, Pancreatic cancer, Bladder cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.