PDPN Mouse Monoclonal Antibody [Clone ID: 18H5]

CAT#: DM3500

PDPN mouse monoclonal antibody, clone 18H5, Supernatant

Product Images

DM3500 Podoplanin antibody staining of Paraffin Embedded Human Mucosa Sections.

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  DM3500 Podoplanin antibody Immunostaining of Human Lymphatic Endothelial Cells.

Specifications

Product Data

• Clone Name: 18H5
• Applications: FC, IF, IHC, IP, WB
• Recommended Dilution: Flow Cytometry: 1/50.
  Immunoprecipitation: 1/50.
  Western blot: 1/100.
  Immunohistochemistry on Frozen and Paraffin Embedded Sections: 1/50-1/200.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody will detect Podoplanin on the surface of lymphatic endothelial cells and kidney podocytes by Immunostaining or Immunohistochemistry.
• Formulation: State: Supernatant
  State: Liquid Concentrated Tissue Culture Supernatant
  Preservative: 0.09% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: podoplanin
• Database Link:
  Entrez Gene 10630 Human
  UniProt ID Q86YL7
• Background: Podoplanin is a well-recognized lymphatic endothelium marker, which can be used to reliably distinguish lymphatic vessels from blood vessels. Podoplanin is a Mr 38,000 membrane mucoprotein that was originally detected on the surface of rat glomerular epithelial cells (podocytes) and was found to be linked to flattening of foot processes that occurs in glomerular diseases. Podoplanin shows features of a membrane mucoprotein with several conserved O-glycosylation sites. Currently, it is of unknown biological function. Because heavily O-glycosylated mucoproteins were identified recently as counterreceptors for selectins that mediate adhesion of inflammatory cells, it is possible that podoplanin plays a similar role in lymphatic endothelia.
• Synonyms: Glycoprotein 36, PA2.26 antigen, T1-alpha, Aggrus, PDPN, GP36, PSEC0003, PSEC0025