BACE2 Rabbit Polyclonal Antibody

CAT#: AP05097PU-N

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Rabbit Polyclonal Anti-BACE2 Antibody, Purified


 Product Datasheet for 'AP05097PU-N'

USD 600.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Applications WB
Recommend Dilution WB
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 44 to 59 of human BACE2
Formulation Phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Concentration Lot specific
Purification Liquid purified Ig
Purified
Predicted Protein Size 49.8 kDa
Gene Name beta-site APP-cleaving enzyme 2
Background Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer¡¯s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g -sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 14 - 9. BACE2 also cleaves APP at b-site and at a different site within Ab8. BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome.
Synonyms AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Reference Data
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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