BACE2 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-BACE2 Antibody, Purified
Product Datasheet for 'AP05097PU-N'
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|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide corresponding to amino acids 44 to 59 of human BACE2|
|Formulation||Phosphate buffered saline solution containing 0.02% sodium azide as a preservative|
|Purification||Liquid purified Ig
|Predicted Protein Size||49.8KDa|
|Gene Name||beta-site APP-cleaving enzyme 2|
|Background||Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer¡¯s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g -sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 14 - 9. BACE2 also cleaves APP at b-site and at a different site within Ab8. BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome.|
|Protein Families||Transmembrane, Protease, Druggable Genome|
|Protein Pathways||Alzheimer's disease|