HDAC1 Mouse Monoclonal Antibody [Clone ID: 5C11]
HDAC1 mouse monoclonal antibody, clone 5C11, Purified
|Applications||ELISA, IF, IHC, PLA, WB|
Immunofluorescence: 10 µg/ml.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/500 - 1/1000.
|Reactivity||Human, Mouse, Rat|
|Immunogen||HDAC1 antibody was raised against hDAC1 (AAH00301, 1 a.a. ~ 483 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Specificity||This antibody reacts to HDAC1.|
|Formulation||PBS, pH 7.2
State: Liquid purified Ig fraction
|Purification||Affinity chromatography on Protein A|
|Storage||Store the antibody at -20°C to -80°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Gene Name||Homo sapiens histone deacetylase 1 (HDAC1)|
|Background||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.|
|Synonyms||Histone deacetylase 1, HD1, RPD3L1|
|Protein Families||Adult stem cells, Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors|
|Protein Pathways||Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.