HDAC1 Mouse Monoclonal Antibody [Clone ID: 5C11]

CAT#: AM31797PU-N

Reviews ()
Write a review

HDAC1 mouse monoclonal antibody, clone 5C11, Purified



USD 480.00


Availability*
2 Weeks

Size
    • 50 ug


Specifications

Product Data
Clone Name 5C11
Applications ELISA, IF, IHC, PLA, WB
Recommended Dilution ELISA.
Immunofluorescence: 10 µg/ml.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
PLA.
Western Blot: 1/500 - 1/1000.
Reactivity Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen HDAC1 antibody was raised against hDAC1 (AAH00301, 1 a.a. ~ 483 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity This antibody reacts to HDAC1.
Formulation PBS, pH 7.2
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity chromatography on Protein A
Storage Store the antibody at -20°C to -80°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens histone deacetylase 1 (HDAC1)
Background Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.
Synonyms Histone deacetylase 1, HD1, RPD3L1
Reference Data
Protein Families Adult stem cells, Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors
Protein Pathways Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer
Other products for "HDAC1"
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies