TNFRSF4 Human Recombinant Protein

CAT#: TP723945

Human OX40 Protein, hFc-His tag

Product Images

Figure 1. Human OX40 Protein, hFc-His Tag on SDS-PAGE under reducing condition.

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  Figure 2. HEK293 cell line transfected with irrelevant protein (B) and human OX40 Ligand (A) were surface stained with Human OX40, hFc-His tagged protein (TP723945) 1 µg/ml followed by Alexa 488-conjugated anti-human IgG secondary antibody.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  OX40（Leu29-Ala216）+hFc（Glu99-Ala330）+6×His tag
• Tag: C-Human Fc and 6×His
• Predicted MW: 47.2 kDa
• Purity: > 95%
• Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
• Reconstitution: Reconstitute with deionized water
• Preparation: Affinity purification
• Applications: Flow Cyt
• Storage: Store the lyophilized protein at -20°C.
  After reconstitution, store the protein at -80°C for 12 months.
  Avoid repeated freezing and thawing.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 7293
• UniProt ID: P43489
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.