TNFRSF4 (NM_003327) Human Mass Spec Standard

CAT#: PH311253

TNFRSF4 MS Standard C13 and N15-labeled recombinant protein (NP_003318)

Product Images

Coomassie blue staining of purified TNFRSF4 protein (Cat# TP311253). The protein was produced from HEK293T cells transfected with TNFRSF4 cDNA clone (Cat# RC211253) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Tag: C-Myc/DDK
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: RC211253
• Predicted MW: 29.3 kDa
• Protein Sequence:
  Sequence Link

  >RC211253 protein sequence
  Red=Cloning site Green=Tags(s)
  
  MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPG
  FYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQA
  CKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVP
  GGRAVAAILGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Labeling Method: Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3
• Storage: Store at -80°C. Avoid repeated freeze-thaw cycles.
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.

Reference Data

• RefSeq: NP_003318
• RefSeq Size: 1120
• RefSeq ORF: 831
• Synonyms: ACT35; CD134; IMD16; OX40; TXGP1L
• Locus ID: 7293
• UniProt ID: P43489
• Cytogenetics: 1p36.33
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
• Protein Families: Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction