CTLA4 (NM_005214) Human Recombinant Protein

CAT#: TP723874

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Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1


Product Datasheet for 'TP723874'


  View other "CTLA4" proteins (7)

USD 150.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence Human CTLA-4, the region of Ala37-Phe162, from gene Accession# NM_005214
Tag Fc chimera
Predicted MW 39.9 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >95%, as determined by Coomassie stained SDS-PAGE
Buffer 1 x PBS
Bioactivity The ED50 is 75 - 375 ng/ml, corresponding to a specific activity of 0.2-1.3 x 104 units/mg, determined by the dose dependent inhibition of IL-2 production induced by 0.5 µg/ml of CD80 on Jurkat cells.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_005205
Locus ID 1493
Refseq Size 1997
Cytogenetics 2q33.2
Refseq ORF 669
Synonyms ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Summary This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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