Slx4 Mouse Gene Knockout Kit (CRISPR)

CAT#: KN316266RB

Slx4 - mouse gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: Slx4
• Locus ID: 52864
• Components:

  KN316266G1, Slx4 gRNA vector 1 in pCas-Guide CRISPR vector

  KN316266G2, Slx4 gRNA vector 2 in pCas-Guide CRISPR vector

  KN316266RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_177472
• UniProt ID: Q6P1D7
• Synonyms: AI256635; AI426760; Btbd12; D16Bwg1016e
• Summary: This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013]