IMP3 (IGF2BP3) Human Gene Knockout Kit (CRISPR)

CAT#: KN209597RB

IGF2BP3 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: IMP3
• Locus ID: 10643
• Components:

  KN209597G1, IMP3 gRNA vector 1 in pCas-Guide CRISPR vector

  KN209597G2, IMP3 gRNA vector 2 in pCas-Guide CRISPR vector

  KN209597RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_006547
• UniProt ID: O00425
• Synonyms: CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3
• Summary: The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]