Mouse Irf2bpl activation kit by CRISPRa

CAT#: GA214790

Irf2bpl CRISPRa kit - CRISPR gene activation of mouse interferon regulatory factor 2 binding protein-like

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Irf2bpl
• Locus ID: 238330
• Kit Components:

  GA214790G1, Irf2bpl gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA214790G2, Irf2bpl gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA214790G3, Irf2bpl gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_145836
• UniProt ID: Q8K3X4
• Synonyms: 6430527G18Rik; Eap1
• Summary: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity).[UniProtKB/Swiss-Prot Function]