Mouse Rap1a activation kit by CRISPRa

CAT#: GA212265

Rap1a CRISPRa kit - CRISPR gene activation of mouse RAS-related protein 1a

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Rap1a
• Locus ID: 109905
• Kit Components:

  GA212265G1, Rap1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212265G2, Rap1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212265G3, Rap1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_145541
• UniProt ID: P62835
• Synonyms: AI848598; G-22K; Krev-1; Rap1
• Summary: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.[UniProtKB/Swiss-Prot Function]