Mouse Adipor2 activation kit by CRISPRa

CAT#: GA207820

Adipor2 CRISPRa kit - CRISPR gene activation of mouse adiponectin receptor 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Adipor2
• Locus ID: 68465
• Kit Components:

  GA207820G1, Adipor2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207820G2, Adipor2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207820G3, Adipor2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_197985, NM_001355692
• UniProt ID: Q8BQS5
• Synonyms: 1110001I14Rik; ADCR2; AI115388; AW554121; D6Ucla1e; Paqr2
• Summary: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). Required for normal body fat and glucose homeostasis (PubMed:17327425, PubMed:17068142, PubMed:17268472, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake (PubMed:12802337, PubMed:17268472, PubMed:24742672). Has intermediate affinity for globular and full-length adiponectin (PubMed:12802337). Required for normal revascularization after chronic ischemia caused by severing of blood vessels (PubMed:24742672).[UniProtKB/Swiss-Prot Function]