Mouse Ppm1d activation kit by CRISPRa

CAT#: GA205617

Ppm1d CRISPRa kit - CRISPR gene activation of mouse protein phosphatase 1D magnesium-dependent, delta isoform

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ppm1d
• Locus ID: 53892
• Kit Components:

  GA205617G1, Ppm1d gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205617G2, Ppm1d gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205617G3, Ppm1d gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016910
• UniProt ID: Q9QZ67
• Synonyms: AV338790; Wip1
• Summary: Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (PubMed:24135283).[UniProtKB/Swiss-Prot Function]