Mouse Ptch1 activation kit by CRISPRa

CAT#: GA203442

Ptch1 CRISPRa kit - CRISPR gene activation of mouse patched 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ptch1
• Locus ID: 19206
• Kit Components:

  GA203442G1, Ptch1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203442G2, Ptch1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203442G3, Ptch1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001328514, NM_008957
• UniProt ID: Q61115
• Synonyms: A230106A15Rik; mes; Ptc; Ptc1; Ptch
• Summary: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.[UniProtKB/Swiss-Prot Function]