Mouse Itgav activation kit by CRISPRa

CAT#: GA202201

Itgav CRISPRa kit - CRISPR gene activation of mouse integrin alpha V

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Itgav
• Locus ID: 16410
• Kit Components:

  GA202201G1, Itgav gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202201G2, Itgav gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202201G3, Itgav gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008402
• UniProt ID: P43406
• Synonyms: 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik
• Summary: This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]