Mouse Insr activation kit by CRISPRa

CAT#: GA202177

Insr CRISPRa kit - CRISPR gene activation of mouse insulin receptor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Insr
• Locus ID: 16337
• Kit Components:

  GA202177G1, Insr gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202177G2, Insr gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202177G3, Insr gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010568
• UniProt ID: P15208
• Synonyms: 4932439J01Rik; CD220; D630014A15Rik; IR; IR-A; IR-B
• Summary: This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]