Mouse Ddr1 activation kit by CRISPRa

CAT#: GA200491

Ddr1 CRISPRa kit - CRISPR gene activation of mouse discoidin domain receptor family, member 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ddr1
• Locus ID: 12305
• Kit Components:

  GA200491G1, Ddr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200491G2, Ddr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200491G3, Ddr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198831, NM_001198833, NM_007584, NM_172962
• UniProt ID: Q03146
• Synonyms: 6030432F18; AI323681; Cak; CD167a; Nep; PTK3A
• Summary: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.[UniProtKB/Swiss-Prot Function]