Human NALP12 (NLRP12) activation kit by CRISPRa

CAT#: GA114138

NLRP12 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 12

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NLRP12
• Locus ID: 91662
• Kit Components:

  GA114138G1, NALP12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114138G2, NALP12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114138G3, NALP12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277126, NM_001277129, NM_033297, NM_144687
• UniProt ID: P59046
• Synonyms: CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2
• Summary: This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]