Human MIB1 activation kit by CRISPRa

CAT#: GA111567

MIB1 CRISPRa kit - CRISPR gene activation of human mindbomb E3 ubiquitin protein ligase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MIB1
• Locus ID: 57534
• Kit Components:

  GA111567G1, MIB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111567G2, MIB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111567G3, MIB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020774
• UniProt ID: Q86YT6
• Synonyms: DIP-1; DIP1; LVNC7; MIB; ZZANK2; ZZZ6
• Summary: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]