Human TAK1 (MAP3K7) activation kit by CRISPRa

CAT#: GA104744

MAP3K7 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 7

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MAP3K7
• Locus ID: 6885
• Kit Components:

  GA104744G1, TAK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104744G2, TAK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104744G3, TAK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003188, NM_145331, NM_145332, NM_145333
• UniProt ID: O43318
• Synonyms: MEKK7; TAK1; TGF1a
• Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]