Human MAX activation kit by CRISPRa

CAT#: GA102827

MAX CRISPRa kit - CRISPR gene activation of human MYC associated factor X

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MAX
• Locus ID: 4149
• Kit Components:

  GA102827G1, MAX gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102827G2, MAX gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102827G3, MAX gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271068, NM_001271069, NM_002382, NM_145112, NM_145113, NM_145114, NM_145116, NM_197957, NR_073137, NR_073138, NM_001320415
• UniProt ID: P61244
• Synonyms: bHLHd4
• Summary: The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]