Human Cytokeratin 5 (KRT5) activation kit by CRISPRa

CAT#: GA102614

KRT5 CRISPRa kit - CRISPR gene activation of human keratin 5

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: KRT5
• Locus ID: 3852
• Kit Components:

  GA102614G1, Cytokeratin 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102614G2, Cytokeratin 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102614G3, Cytokeratin 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000424
• UniProt ID: P13647
• Synonyms: CK5; DDD; DDD1; EBS2; K5; KRT5A
• Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]