Human Insulin Receptor (INSR) activation kit by CRISPRa

CAT#: GA102443

INSR CRISPRa kit - CRISPR gene activation of human insulin receptor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: INSR
• Locus ID: 3643
• Kit Components:

  GA102443G1, Insulin Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102443G2, Insulin Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102443G3, Insulin Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000208, NM_001079817
• UniProt ID: P06213
• Synonyms: CD220; HHF5
• Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]