Human RBPJK (RBPJ) activation kit by CRISPRa

CAT#: GA102364

RBPJ CRISPRa kit - CRISPR gene activation of human recombination signal binding protein for immunoglobulin kappa J region

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: RBPJ
• Locus ID: 3516
• Kit Components:

  GA102364G1, RBPJK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102364G2, RBPJK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102364G3, RBPJK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005349, NM_015874, NM_203283, NM_203284, NM_001363577
• UniProt ID: Q06330
• Synonyms: AOS3; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH
• Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]