Human Factor D (CFD) activation kit by CRISPRa

CAT#: GA101185

CFD CRISPRa kit - CRISPR gene activation of human complement factor D

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CFD
• Locus ID: 1675
• Kit Components:

  GA101185G1, Factor D gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101185G2, Factor D gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101185G3, Factor D gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317335, NM_001928
• UniProt ID: P00746
• Synonyms: ADIPSIN; ADN; DF; PFD
• Summary: This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]