Human CYLD activation kit by CRISPRa

CAT#: GA101089

CYLD CRISPRa kit - CRISPR gene activation of human CYLD lysine 63 deubiquitinase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CYLD
• Locus ID: 1540
• Kit Components:

  GA101089G1, CYLD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101089G2, CYLD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101089G3, CYLD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042355, NM_001042412, NM_015247, NM_016385
• UniProt ID: Q9NQC7
• Synonyms: BRSS; CDMT; CYLD1; CYLDI; EAC; MFT; MFT1; SBS; TEM; USPL2
• Summary: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]