Human beta Catenin (CTNNB1) activation kit by CRISPRa

CAT#: GA101060

CTNNB1 CRISPRa kit - CRISPR gene activation of human catenin beta 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CTNNB1
• Locus ID: 1499
• Kit Components:

  GA101060G1, beta Catenin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101060G2, beta Catenin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101060G3, beta Catenin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098209, NM_001098210, NM_001904, NM_001330729
• UniProt ID: P35222
• Synonyms: armadillo; CTNNB; MRD19
• Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]