Human RHOC activation kit by CRISPRa

CAT#: GA100279

RHOC CRISPRa kit - CRISPR gene activation of human ras homolog family member C

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: RHOC
• Locus ID: 389
• Kit Components:

  GA100279G1, RHOC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100279G2, RHOC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100279G3, RHOC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042678, NM_001042679, NM_175744
• UniProt ID: P08134
• Synonyms: ARH9; ARHC; H9; RHOH9
• Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]