Human Activin A Receptor Type IB (ACVR1B) activation kit by CRISPRa

CAT#: GA100057

ACVR1B CRISPRa kit - CRISPR gene activation of human activin A receptor type 1B

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ACVR1B
• Locus ID: 91
• Kit Components:

  GA100057G1, Activin A Receptor Type IB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100057G2, Activin A Receptor Type IB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100057G3, Activin A Receptor Type IB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004302, NM_020327, NM_020328
• UniProt ID: P36896
• Synonyms: ACTRIB; ACVRLK4; ALK4; SKR2
• Summary: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]