Slingshot homolog 1 (SSH1) (NM_001161330) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC228537L3V
- LentiORF®
Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 2, 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
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USD 365.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Slingshot homolog 1 |
Synonyms | SSH1L |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001161330 |
ORF Size | 2076 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC228537).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001161330.1 |
RefSeq ORF | 2079 bp |
Locus ID | 54434 |
UniProt ID | Q8WYL5 |
Cytogenetics | 12q24.11 |
Protein Families | Druggable Genome, Phosphatase |
Protein Pathways | Regulation of actin cytoskeleton |
MW | 77.2 kDa |
Gene Summary | The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
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