Neurofibromin (NF1) (NM_001128147) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC226001L3V

Lenti ORF particles, NF1 (Myc-DDK tagged) - Human neurofibromin 1 (NF1), transcript variant 3, 200ul, >10^7 TU/mL

Product Images

RC226001L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC226001L3V particle to overexpress human NF1-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Neurofibromin
• Synonyms: NFNS; VRNF; WSS
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_001128147
• ORF Size: 1779 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC226001).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001128147.1
• RefSeq ORF: 1782 bp
• Locus ID: 4763
• UniProt ID: P21359
• Cytogenetics: 17q11.2
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway
• MW: 67.4 kDa
• Gene Summary: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]