GRIK1 (NM_000830) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC222898L2V

Lenti ORF particles, GRIK1 (mGFP-tagged)-Human glutamate receptor, ionotropic, kainate 1 (GRIK1), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: GRIK1
• Synonyms: EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_000830
• ORF Size: 2754 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC222898).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000830.3
• RefSeq Size: 3231 bp
• RefSeq ORF: 2757 bp
• Locus ID: 2897
• UniProt ID: P39086
• Cytogenetics: 21q21.3
• Domains: lig_chan, ANF_receptor
• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction
• MW: 104 kDa
• Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]