SLIT1 (NM_003061) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC218562L4V

Lenti ORF particles, SLIT1 (mGFP-tagged)-Human slit homolog 1 (Drosophila) (SLIT1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: SLIT1
• Synonyms: MEGF4; SLIL1; SLIT-1; SLIT3
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_003061
• ORF Size: 4602 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC218562).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003061.1, NP_003052.1
• RefSeq Size: 5094 bp
• RefSeq ORF: 4605 bp
• Locus ID: 6585
• UniProt ID: O75093
• Cytogenetics: 10q24.1
• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance
• MW: 167.7 kDa
• Gene Summary: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.[UniProtKB/Swiss-Prot Function]