Neurexin 1 (NRXN1) (NM_138735) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC215381L2V

Lenti ORF particles, NRXN1 (mGFP-tagged)-Human neurexin 1 (NRXN1), transcript variant beta, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: NRXN1
• Synonyms: Hs.22998; PTHSL2; SCZD17
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_138735
• ORF Size: 1326 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC215381).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_138735.1
• RefSeq Size: 3712 bp
• RefSeq ORF: 1329 bp
• Locus ID: 9378
• UniProt ID: P58400
• Cytogenetics: 2p16.3
• Domains: LamG
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)
• MW: 42.1 kDa
• Gene Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]