TIP120A (CAND1) (NM_018448) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC208212L4V

Lenti ORF particles, CAND1 (mGFP-tagged) - Human cullin-associated and neddylation-dissociated 1 (CAND1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: TIP120A
• Synonyms: TIP120; TIP120A
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_018448
• ORF Size: 3690 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208212).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_018448.2
• RefSeq Size: 5956 bp
• RefSeq ORF: 3693 bp
• Locus ID: 55832
• UniProt ID: Q86VP6
• Cytogenetics: 12q14.3-q15
• Domains: TIP120
• Protein Families: Transcription Factors
• MW: 136.4 kDa
• Gene Summary: This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]