JAB1 (COPS5) (NM_006837) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200979L3V

Lenti ORF particles, COPS5 (Myc-DDK tagged) - Human COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5), 200ul, >10^7 TU/mL

Product Images

RC200979L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC200979L3V particle to overexpress human COPS5-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: JAB1
• Synonyms: CSN5; JAB1; MOV-34; SGN5
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_006837
• ORF Size: 1002 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200979).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006837.2
• RefSeq Size: 1510 bp
• RefSeq ORF: 1005 bp
• Locus ID: 10987
• UniProt ID: Q92905
• Cytogenetics: 8q13.1
• Domains: JAB_MPN
• Protein Families: Druggable Genome, Protease, Transcription Factors
• MW: 37.6 kDa
• Gene Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]