Cdc14b (NM_001122989) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR218991L4V

Lenti ORF particles, Cdc14b (GFP-tagged) - Mouse CDC14 cell division cycle 14 homolog B (S. cerevisiae) (Cdc14b), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Cdc14b
• Synonyms: 2810432N10Rik; A530086E13Rik; AA472821; Cdc14B1; CDC14B3
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_001122989
• ORF Size: 1344 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR218991).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001122989.1, NP_001116461.1
• RefSeq Size: 5595 bp
• RefSeq ORF: 1347 bp
• Locus ID: 218294
• UniProt ID: Q6PFY9
• Cytogenetics: 13 B3
• Gene Summary: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).[UniProtKB/Swiss-Prot Function]