Nr1h2 (NM_009473) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR207128L3V
- LentiORF®
Lenti ORF particles, Nr1h2 (Myc-DDK-tagged) - Mouse nuclear receptor subfamily 1, group H, member 2 (Nr1h2), 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
AAV Particle: DDK
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USD 365.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | Nr1h2 |
Synonyms | AI194859; LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1; RIP15; Unr; Unr2; UR |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_009473 |
ORF Size | 1341 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR207128).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_009473.2, NP_033499.1 |
RefSeq Size | 2029 bp |
RefSeq ORF | 1341 bp |
Locus ID | 22260 |
UniProt ID | Q60644 |
Cytogenetics | 7 B3 |
Gene Summary | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).[UniProtKB/Swiss-Prot Function] |
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