Cmtm6 (NM_026036) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR201673L4V

Lenti ORF particles, Cmtm6 (GFP-tagged) - Mouse CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Cmtm6
• Synonyms: 2810051A14Rik; AA536733; Cklfsf6
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_026036
• ORF Size: 552 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR201673).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_026036.1
• RefSeq Size: 3352 bp
• RefSeq ORF: 552 bp
• Locus ID: 67213
• UniProt ID: Q9CZ69
• Cytogenetics: 9 F3
• Gene Summary: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.[UniProtKB/Swiss-Prot Function]