PTPRN2 (NM_130843) Human Untagged Clone

CAT#: SC305917

PTPRN2 (untagged)-Human protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRN2
• Synonyms: IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_130843, the custom clone sequence may differ by one or more nucleotides
  ATGGGGCCGCCGCTCCCGCTGCTGCTGCTGCTACTGCTGCTGCTGCCGCCACGCGTCCTG
  CCTGCCGCCCCTTCGTCCGTCCCCCGCGGCCGGCAGCTCCCGGGGCGTCTGGGCTGCCTG
  CTCGAGGAGGGCCTCTGCGGAGCGTCCGAGGCCTGTGTGAACGATGGAGTGTTTGGAAGG
  TGCCAGAAGGTTCCGGCAATGGACTTTTACCGCTACGAGGTGTCGCCCGTGGCCCTGCAG
  CGCCTGCGCGTGGCGTTGCAGAAGCTTTCCGGCACAGGTTTCACGTGGCAGGATGACTAT
  ACTCAGTATGTGATGGACCAGGAACTTGCAGACCTCCCGAAAACCTACCTGAGGCGTCCT
  GAAGCATCCAGCCCAGCCAGGCCCTCAAAACACAGCGTTGGCAGCGAGAGGAGGTACAGT
  CGGGAGGGCGGTGCTGCCCTGGCCAACGCCCTCCGACGCCACCTGCCCTTCCTGGAGGCC
  CTGTCCCAGGCCCCAGCCTCAGACGTGCTCGCCAGGACCCATACGGCGCAGGACAGACCC
  CCCGCTGAGGGTGATGACCGCTTCTCCGAGAGCATCCTGACCTATGTGGCCCACACGTCT
  GCGCTGACCTACCCTCCCGGGTCCCGGACCCAGCTCCGCGAGGACCTCCTGCCGCGGACC
  CTCGGCCAGCTCCAGCCAGATGAGCTCAGCCCTAAGGTGGACAGTGGTGTGGACAGACAC
  CATCTGATGGCGGCCCTCAGTGCCTATGCTGCCCAGAGGCCCCCAGCTCCCCCCGGGGAG
  GGCAGCCTGGAGCCACAGTACCTTCTGCGTGCACCCTCAAGAATGCCCAGGCCTTTGCTG
  GCACCAGCCGCCCCCCAGAAGTGGCCTTCACCTCTGGGAGATTCCGAAGACCCCTCCAGC
  ACAGGCGATGGAGCACGGATTCATACCCTCCTGAAGGACCTGCAGAGGCAGCCGGCTGAG
  GTGAGGGGCCTGAGTGGCCTGGAGCTGGACGGCATGGCTGAGCTGATGGCTGGCCTGATG
  CAAGGCGTGGACCATGGAGTAGCTCGAGGCAGCCCTGGGAGAGCGGCCCTGGGAGAGTCT
  GGAGAACAGGCGGATGGCCCCAAGGCCACCCTCCGTGGAGACAGCTTTCCAGATGACGGA
  GTGCAGGACGACGATGATAGACTTTACCAAGAGGTCCATCGTCTGAGTGCCACACTCGGG
  GGCCTCCTGCAGGACCACGGGTCTCGACTCTTACCTGGAGCCCTCCCCTTTGCAAGGCCC
  CTCGACATGGAGAGGAAGAAGTCCGAGCACCCTGAGTCTTCCCTGTCTTCAGAAGAGGAG
  ACTGCCGGAGTGGAGAACGTCAAGAGCCAGACGTATTCCAAAGATCTGCTGGGGCAGCAG
  CCGCATTCGGAGCCCGGGGCCGCTGCGTTTGGGGAGCTCCAAAACCAGATGCCTGGGCCC
  TCGAAGGAGGAGCAGAGCCTTCCAGCGGGTGCTCAGGAGGCCCTCAGCGACGGCCTGCAA
  TTGGAGGTCCAGCCTTCCGAGGAAGAGGCGCGGGGCTACATCGTGACAGACAGAGAGGTT
  CTCGGACCAGCAGTGACCTTCAAAGTGAGCGCCAATGTCCAAAACGTGACCACTGAGGAT
  GTGGAGAAGGCCACAGTTGACAACAAAGACAAACTGGAGGAAACCTCTGGACTGAAAATT
  CTTCAAACCGGAGTCGGGTCGAAAAGCAAACTCAAGTTCCTGCCTCCTCAGGCGGAGCAA
  GAAGACTCCACCAAGTTCATCGCGCTCACCCTGGTCTCCCTCGCCTGCATCCTGGGCGTC
  CTCCTGGCCTCTGGCCTCATCTACTGCCTCCGCCATAGCTCTCAGCACAGGCTGAAGGAG
  AAGCTCTCGGGACTAGGGGGCGACCCAGGTGCAGATGCCACTGCCGCCTACCAGGAGCTG
  TGCCGCCAGCGTATGGCCACGCGGCCACCAGACCGACCTGAGGGCCCGCACACGTCACGC
  ATCAGCAGCGTCTCATCCCAGTTCAGCGACGGGCCGATCCCCAGCCCCTCCGCACGCAGC
  AGCGCCTCATCCTGGTCCGAGGAGCCTGTGCAGTCCAACATGGACATCTCCACCGGCCAC
  ATGATCCTGTCCTACATGGAGGACCACCTGAAGAACAAGAACCGGCTGGAGAAGGAGTGG
  GAAGCGCTGTGCGCCTACCAGGCGGAGCCCAACAGCTCGTTCGTGGCCCAGAGGGAGGAG
  AACGTGCCCAAGAACCGCTCCCTGGCCGTGCTGACCTATGACCACTCCCGGGTCCTGCTG
  AAGGCGGAGAACAGCCACAGCCACTCAGACTACATCAACGCTAGCCCCATCATGGATCAC
  GACCCGAGGAACCCCGCGTACATCGCCACCCAGGGACCGCTGCCCGCCACCGTGGCTGAC
  TTTTGGCAGATGGTGTGGGAGAGCGGCTGCGTGGTGATCGTCATGCTGACACCCCTCGCG
  GAGAACGGCGTCCGGCAGTGCTACCACTACTGGCCGGATGAAGGCTCCAATCTCTACCAC
  ATCTATGAGGTGAACCTGGTCTCCGAGCACATCTGGTGTGAGGACTTCCTGGTGAGGAGC
  TTCTATCTGAAGAACCTGCAGACCAACGAGACGCGCACCGTGACGCAGTTCCACTTCCTG
  AGTTGGTATGACCGAGGAGTCCCTTCCTCCTCAAGGTCCCTCCTGGACTTCCGCAGAAAA
  GTAAACAAGTGCTACAGGGGCCGTTCTTGTCCAATAATTGTTCATTGCAGTGACGGTGCA
  GGCCGGAGCGGCACCTACGTCCTGATCGACATGGTTCTCAACAAGATGGCCAAAGGTGCT
  AAAGAGATTGATATCGCAGCGACCCTGGAGCACTTGAGGGACCAGAGACCCGGCATGGTC
  CAGACGAAGGAGCAGTTTGAGTTCGCGCTGACAGCCGTGGCTGAGGAGGTGAACGCCATC
  CTCAAGGCCCTTCCCCAGTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_130843
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_130843.1, NP_570858.1
• RefSeq Size: 4680 bp
• RefSeq ORF: 2961 bp
• Locus ID: 5799
• UniProt ID: Q92932
• Cytogenetics: 7q36.3
• Domains: Y_phosphatase, PTPc_motif
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Type I diabetes mellitus
• Gene Summary: This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
  Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.