AOC2 (NM_009590) Human Untagged Clone

CAT#: SC303923

AOC2 (untagged)-Human amine oxidase, copper containing 2 (retina-specific) (AOC2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AOC2
• Synonyms: DAO2; RAO; SSAO
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_009590 edited
  TGTTAGAATTCTGATTTCAGCTCTCAGCATCCACCATGCATCTCAAGATAGTCCTGGCGT
  TCCTGGCACTGTCCCTCATTACCATCTTTGCCCTGGCCTATGTTTTGCTGACCAGCCCAG
  GTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTATCCCATAGGGCCCAGCCCTGGCCAC
  ACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGCCGAGAGGAGTTGACAGCTGTGATGC
  GCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTGGACGCAGCCCAGGCTCAGCCCTCGG
  ACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCCCCCAAGGCTGCAGCCCTGGCCCACC
  TGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCACTGGCCATCGTCCTCTTTGGTGGAC
  AACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGGCCGCTGCCTCACCCCTCGTACATGC
  GGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTGCCCTATCACCGTCGCCCGGTGCTGA
  GAGCTGAGTTTACACAGATGTGGAGGCATCTGAAAGAGGTGGAGCTACCCAAGGCACCCA
  TCTTCCTGTCGTCCACCTTCAACTACAATGGCTCTACCCTGGCAGCTGTGCATGCCACCC
  CTCGGGGCTTGCGCTCAGGGGACCGAGCTACCTGGATGGCCCTCTACCATAACATCTCAG
  GGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAGCTACTACTGGACCACAGGGCCCTGG
  ACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTACCTTGGGCACTACTATGCAGACTTGG
  GCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTGGAAGTGGTTAGAGTCCCTCTACCTC
  CACCAAATGGAGCTTCATCCCTGAGGTCTCGGAACTCTCCAGGTCCTCTTCCCCCTCTTC
  AGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAAGGAAACCTGGTGGTATCCTCCCTCT
  GGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGCCTGAGGATTTTTGATGTTCGGTTCC
  AGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAGGAGTGTGTATCTATCTATGGTGCCG
  ATTCACCCAAGACGATGCTGACTCGCTATTTGGATAGCAGCTTTGGACTCGGCCGTAACA
  GCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTATCAAGCCACGATGGTGGACATCCATA
  TATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCAGGGGCTGTGTGTGTATTTGAGGAAG
  CCCAGGGACTGCCCCTTCGAAGGCACCACAATTACCTTCAAAATCATTTCTATGGTGGTT
  TGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCATCTGTGGGCAACTATGACTACATTT
  GGGACTTTGTGTTGTACCCAAATGGGGCACTTGAAGGGCGGGTCCATGCCACGGGTTATA
  TCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGCCTCCTCTTTGGGAACCGTGTGGGGG
  AAAGAGTGCTGGGAACGGTGCACACACATGCCTTCCACTTCAAGCTGGACCTGGATGTGG
  CAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTGGTGTTTAAACCTGTGGCTGCCCCCT
  GGAACCCGGAGCACTGGCTACAGCGCCCACAGCTGACTCGGCAGGTCCTGGGAAAGGAGG
  ACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCCCGCTACCTCTACCTGGCTAGCAACC
  AGACTAATGCGTGGGGTCACCAGCGCGGGTACCGAATCCAGATCCACAGCCCCCTTGGCA
  TACACATACCCCTGGAGAGTGACATGGAGAGGGCCCTCAGCTGGGGGAGATACCAGCTTG
  TGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAATGACA
  TCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGAGAGG
  ATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATCCCAA
  ACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTTGATG
  AGGACCCCTCCATCTTCTCCCCTGGCAGTGTCTACTTTGAGAAGGGCCAGGATGCTGGGC
  TCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGACTTAC
  CCCCTTTCTCTTACCACGGCTTCTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_009590 unedited
  NNNNGGGGAGTCATATTTGTATACGACTCATATAGGCGGCCGCGNATTCATGCATCTCAA
  NATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTGGCCTATGTTTT
  GCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTATCCCATAGGGC
  CCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGCCGAGAGGAGTT
  GACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTGGACGCAGCCCA
  GGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCCCCCAAGGCTGC
  AGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCACTGGCCATCGT
  CCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGGCCGCTGCCTCA
  CCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTGCCCTATCACCG
  TCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGANAGAGGTGGAGCT
  ACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCTACCCTGGCAGC
  TGTGCATGCCACCCCTCGGGGCTTGCGCTCAGGGGACCGAGCTACCTGGATGGCCCTCTA
  CCATACATCTCAGGNGTTGGTCTTTTCCTCACCCCGTGGGGCTGGAGCTACTACTGGACC
  ACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTACCTGGGCACTACTA
  TGCAGACTTGGGCCAAGTGGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_009590 unedited
  NNGGGTGCCGCCATTGGGNNGATGGCAACTTCCCAGGNCCAGAAAAGCACTGGGGNAGGG
  TCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAG
  AGTCGAGCTAGAAGCCGTGGTAAGAGAAAGGGGGTAAGTCCGGGACACAGGCTGCCAGGT
  CGGGGAGGCAGGCCACAGGATTGATGCTGCAGAGCCCAGCATCCTGGCCCTTCTCAAAGT
  AGACACTGCCAGGGGAGAAGATGGAGGGGTCCTCATCAAAGAAGTTATAGGGTCGGAGCA
  AGAAGCCAACTCTGTTCCCCAGAGTCACTGTGTTTGGGATGTCCTCGGCATGGGGAATGT
  GCAGGAAGCTGGCTGTGACCCAAGCCACCAGATCCTCTCCTAAGAGGGTTTCATTGTTGA
  TGAAGTCAGCAAAGGTAACTGTGGGTGTCCAGATGTCATTCTGGTGATAGATGCTACTGC
  TCTGTGACTCCTCCTCCTTTCTCTGGGTCACCACAAGCTGGTATCTCCCCCAGCTGAGGG
  CCCTCTCCATGTCACTCTCCAGGGGTATGTGTATGCCAAGGGGGCTGTGGATCTGGATTC
  GGTACCCGCGCTGGTGACCCCACGCATTAGTCTGGTTGCTAGCCAGGTAGAGGTAGCGGG
  GTAGGGGGCTTCCCAGGAAAAAGCTGTCAGGTCCTCCTTTTCCAGGACCTGCCGAGTCAG
  CTGTGGGCGCTGTAGCCAGTGCTCCGGGTTCCAGGGGGGCAGCCACAGGGTTTAAACACC
  ACGTCTTCAGCTACCACCCAGTTTTTCAGCCCTGCCACATCCAGGTCCANCTTGAAATGG
  AAAGCATGTGTTTGCACCGTTCCAACATCTTTTCCCCAAACGGTTCAAAAAAGGAGCCCT
  CCCTTTCCC
  
• Restriction Sites: Please inquire
• ACCN: NM_009590
• Insert Size: 2300 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_009590.2, NP_033720.2
• RefSeq Size: 2681 bp
• RefSeq ORF: 2271 bp
• Locus ID: 314
• UniProt ID: O75106
• Cytogenetics: 17q21.31
• Protein Families: Transmembrane
• Protein Pathways: beta-Alanine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Phenylalanine metabolism, Tyrosine metabolism
• Gene Summary: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).