Integrin alpha 3 (ITGA3) (NM_002204) Human Untagged Clone

CAT#: SC303147

ITGA3 (untagged)-Human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant a

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ITGA3
• Synonyms: CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002204 edited
  ATGGGCCCCGGCCCCAGCCGCGCGCCCCGCGCCCCACGCCTGATGCTCTGTGCGCTCGCC
  TTGATGGTGGCGGCCGGCGGCTGCGTCGTCTCCGCCTTCAACCTGGATACCCGATTCCTG
  GTAGTGAAGGAGGCCGGGAACCCGGGCAGCCTCTTCGGCTACTCGGTCGCCCTCCATCGG
  CAGACAGAGCGGCAGCAGCGCTACCTGCTCCTGGCTGGTGCCCCCCGGGAGCTCGCTGTG
  CCCGATGGCTACACCAACCGGACTGGTGCTGTGTACCTGTGCCCACTCACTGCCCACAAG
  GATGACTGTGAGCGGATGAACATCACAGTGAAAAATGACCCTGGCCATCACATTATTGAG
  GACATGTGGCTTGGAGTGACTGTGGCCAGCCAGGGCCCTGCAGGCAGAGTTCTGGTCTGT
  GCCCACCGCTACACCCAGGTGCTGTGGTCAGGGTCAGAAGACCAGCGGCGCATGGTGGGC
  AAGTGCTACGTGCGAGGCAATGACCTAGAGCTGGACTCCAGTGATGACTGGCAGACCTAC
  CACAACGAGATGTGCAATAGCAACACAGACTACCTGGAGACGGGCATGTGCCAGCTGGGC
  ACCAGCGGTGGCTTCACCCAGAACACTGTGTACTTCGGCGCCCCCGGTGCCTACAACTGG
  AAAGGAAACAGCTACATGATTCAGCGCAAGGAGTGGGACTTATCTGAGTATAGTTACAAG
  GACCCAGAGGACCAAGGAAACCTCTATATTGGGTACACGATGCAGGTAGGCAGCTTCATC
  CTGCACCCCAAAAACATCACCATTGTGACAGGTGCCCCACGGCACCGACATATGGGCGCG
  GTGTTCTTGCTGAGCCAGGAGGCAGGCGGAGACCTGCGGAGGAGGCAGGTGCTGGAGGGC
  TCGCAGGTGGGCGCCTATTTTGGCAGCGCAATTGCCCTGGCAGACCTGAACAATGATGGG
  TGGCAGGACCTCCTGGTGGGCGCCCCCTACTACTTCGAGAGGAAAGAGGAAGTAGGGGGT
  GCCATCTATGTCTTCATGAACCAGGCGGGAACCTCCTTCCCTGCTCACCCCTCACTCCTT
  CTTCATGGCCCCAGTGGCTCTGCCTTTGGTTTATCTGTGGCCAGCATTGGTGACATCAAC
  CAGGATGGATTTCAGGATATTGCTGTGGGAGCTCCGTTTGAAGGCTTGGGCAAAGTGTAC
  ATCTATCACAGTAGCTCTAAGGGGCTCCTTAGACAGCCCCAGCAGGTAATCCATGGAGAG
  AAGCTGGGACTGCCTGGGTTGGCCACCTTCGGCTATTCCCTCAGTGGGCAGATGGATGTG
  GATGAGAACTTCTACCCAGACCTTCTAGTGGGAAGCCTGTCAGACCACATTGTGCTGCTG
  CGGGCCCGGCCAGTCATCAACATCGTCCACAAGACCTTGGTGCCCAGGCCAGCTGTGCTG
  GACCCTGCACTTTGCACGGCCACCTCTTGTGTGCAAGTGGAGCTGTGCTTTGCTTACAAC
  CAGAGTGCCGGGAACCCCAACTACAGGCGAAACATCACCCTGGCCTACACTCTGGAGGCT
  GACAGGGACCGCCGGCCGCCCCGGCTCCGCTTTGCCGGCAGTGAGTCCGCTGTCTTCCAC
  GGCTTCTTCTCCATGCCCGAGATGCGCTGCCAGAAGCTGGAGCTGCTCCTGATGGACAAC
  CTCCGTGACAAACTCCGCCCCATCATCATCTCCATGAACTACTCTTTACCTTTGCGGATG
  CCCGATCGCCCCCGGCTGGGGCTGCGGTCCCTGGACGCCTACCCGATCCTCAACCAGGCA
  CAGGCTCTGGAGAACCACACTGAGGTCCAGTTCCAGAAGGAGTGCGGGCCTGACAACAAG
  TGTGAGAGCAACTTGCAGATGCGGGCAGCCTTCGTGTCAGAGCAGCAGCAGAAGCTGAGC
  AGGCTCCAGTACAGCAGAGACGTCCGGAAATTGCTCCTGAGCATCAACGTGACGAACACC
  CGGACCTCGGAGCGCTCCGGGGAGGACGCCCACGAGGCGCTGCTCACCCTGGTGGTGCCT
  CCCGCCCTGCTGCTGTCCTCAGTGCGCCCCCCCGGGGCCTGCCAAGCTAATGAGACCATC
  TTTTGCGAGCTGGGGAACCCCTTCAAACGGAACCAGAGGATGGAGCTGCTCATCACCTTT
  GAGGTCATCGGGGTGACCCTGCACACAAGGGACCTTCAGGTGCAGCTGCAGCTCTCCACG
  TCGAGTCACCAGGACAACCTGTGGCCCATGATCCTCACTCTGCTGGTGGACTATACACTC
  CAGACCTCGCTTAGCATGGTAAATCACCGGCTACAAAGCTTCTTTGGGGGGACAGTGATG
  GGTGAGTCTGGCATGAAAACTGTGGAGGATGTAGGAAGCCCCCTCAAGTATGAATTCCAG
  GTGGGCCCAATGGGGGAGGGGCTGGTGGGCCTGGGGACCCTGGTCCTAGGTCTGGAGTGG
  CCCTACGAAGTCAGCAATGGCAAGTGGCTGCTGTATCCCACGGAGATCACCGTCCATGGC
  AATGGGTCCTGGCCCTGCCGACCACCTGGAGACCTTATCAACCCTCTCAACCTCACTCTT
  TCTGACCCTGGGGACAGGCCATCATCCCCACAGCGCAGGCGGCGACAGCTGGATCCAGGG
  GGAGGCCAGGGCCCCCCACCTGTCACTCTGGCTGCTGCCAAAAAAGCCAAGTCTGAGACT
  GTGCTGACCTGTGCCACAGGGCGTGCCCACTGTGTGTGGCTAGAGTGCCCCATCCCTGAT
  GCCCCCGTTGTCACCAACGTGACTGTGAAGGCACGAGTGTGGAACAGCACCTTCATCGAG
  GATTACAGAGACTTTGACCGAGTCCGGGTAAATGGCTGGGCTACCCTATTCCTCCGAACC
  AGCATCCCCACCATCAACATGGAGAACAAGACCACGTGGTTCTCTGTGGACATTGACTCG
  GAGCTGGTGGAGGAGCTGCCGGCCGAAATCGAGCTGTGGCTGGTGCTGGTGGCCGTGGGT
  GCAGGGCTGCTGCTGCTGGGGCTGATCATCCTCCTGCTGTGGAAGTGCGGCTTCTTCAAG
  CGAGCCCGCACTCGCGCCCTGTATGAAGCTAAGAGGCAGAAGGCGGAGATGAAGAGCCAG
  CCGTCAGAGACAGAGAGGCTGACCGACGACTACTGA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002204
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to differ from the protein associated to this reference by a single amino acid.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002204.1, NP_002195.1
• RefSeq Size: 4637 bp
• RefSeq ORF: 3156 bp
• Locus ID: 3675
• UniProt ID: P26006
• Cytogenetics: 17q21.33
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer
• Gene Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]