PAX8 (NM_003466) Human Untagged Clone

CAT#: SC122658

PAX8 (untagged)-Human paired box 8 (PAX8), transcript variant PAX8A

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAX8
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003466 edited
  CTTCAGAAGGAGGAGAGACACCGGGCCCAGGGCACCCTCGCGGGCGGACCCAAGCAGTGA
  GGGCCTGCAGCCGGCCGGCCAGGGCAGCGGCAGGCGCGGCCCGGACCTACGGGAGGAAGC
  CCCGAGCCCTCGGCGGGCTGCGAGCGACTCCCCGGCGATGCCTCACAACTCCATCAGATC
  TGGCCATGGAGGGCTGAACCAGCTGGGAGGGGCCTTTGTGAATGGCAGACCTCTGCCGGA
  AGTGGTCCGCCAGCGCATCGTAGACCTGGCCCACCAGGGTGTAAGGCCCTGCGACATCTC
  TCGCCAGCTCCGCGTCAGCCATGGCTGCGTCAGCAAGATCCTTGGCAGGTACTACGAGAC
  TGGCAGCATCCGGCCTGGAGTGATAGGGGGCTCCAAGCCCAAGGTGGCCACCCCCAAGGT
  GGTGGAGAAGATTGGGGACTACAAACGCCAGAACCCTACCATGTTTGCCTGGGAGATCCG
  AGACCGGCTCCTGGCTGAGGGCGTCTGTGACAATGACACTGTGCCCAGTGTCAGCTCCAT
  TAATAGAATCATCCGGACCAAAGTGCAGCAACCATTCAACCTCCCTATGGACAGCTGCGT
  GGCCACCAAGTCCCTGAGTCCCGGACACACGCTGATCCCCAGCTCAGCTGTAACTCCCCC
  GGAGTCACCCCAGTCGGATTCCCTGGGCTCCACCTACTCCATCAATGGGCTCCTGGGCAT
  CGCTCAGCCTGGCAGCGACAAGAGGAAAATGGATGACAGTGATCAGGATAGCTGCCGACT
  AAGCATTGACTCACAGAGCAGCAGCAGCGGACCCCGAAAGCACCTTCGCACGGATGCCTT
  CAGCCAGCACCACCTCGAGCCGCTCGAGTGCCCATTTGAGCGGCAGCACTACCCAGAGGC
  CTATGCCTCCCCCAGCCACACCAAAGGCGAGCAGGGCCTCTACCCGCTGCCCTTGCTCAA
  CAGCACCCTGGACGACGGGAAGGCCACCCTGACCCCTTCCAACACGCCACTGGGGCGCAA
  CCTCTCGACTCACCAGACCTACCCCGTGGTGGCAGATCCTCACTCACCCTTCGCCATAAA
  GCAGGAAACCCCCGAGGTGTCCAGTTCTAGCTCCACCCCTTCCTCTTTATCTAGCTCCGC
  CTTTTTGGATCTGCAGCAAGTCGGCTCCGGGGTCCCGCCCTTCAATGCCTTTCCCCATGC
  TGCCTCCGTGTACGGGCAGTTCACGGGCCAGGCCCTCCTCTCAGGGCGAGAGATGGTGGG
  GCCCACGCTGCCCGGATACCCACCCCACATCCCCACCAGCGGACAGGGCAGCTATGCCTC
  CTCTGCCATCGCAGGCATGGTGGCAGGAAGTGAATACTCTGGCAATGCCTATGGCCACAC
  CCCCTACTCCTCCTACAGCGAGGCCTGGCGCTTCCCCAACTCCAGCTTGCTGAGTTCCCC
  ATATTATTACAGTTCCACATCAAGGCCGAGTGCACCGCCCACCACTGCCACGGCCTTTGA
  CCATCTGTAGTTGCCATGGGGACAGTGGGAGCGACTGAGCAACAGGAGGACTCAGCCTGG
  GACAGGCCCCAGAGAGTCACACAAAGGAATCTTTATTTATTACATGAAAAATAACCACAA
  GTCCAGCATTGCGGCACACTCCCTGTGTGGTTAATTTAATGAACCATGAAAGACAGGATG
  ACCTTGGACAAGGCCAAACTGTCCTCCAAGACTCCTTAATGAGGGGCAGGAGTCCCAGGG
  AAAGAGAACCATGCCATGCTGAAAAAGACAAAATTGAAGAAGAAATGTAGCCCCCAGCCG
  GTACCCACCAAAGGAGAGAAGAAGCAATAGCCGAGGAACTTGGGGGGATGGCGAATGGTT
  CCTGCCCGGGCCCAAGGGGTGCACAGGGCACCTCCATGGCTCCATTATTAACACAACTCT
  AGCAATTATGGACCATAAGCACTTCCCTCCAGCCCACAAGTCACAGCCTGGTGCCGAGGC
  TCTCCTCACCAGCCACCCAGGGAGTCACCTCCCTCAGCCTCCCGCCTGCCCCACACGGAG
  GCTCTGGCTGTCCTCTTTCTCCACTCCATTTGCTTGGCTCTTTCTACACCTCCCTCTTGG
  GCATGGGCTGAGGGCTGGAGCGAGTCCCTCAGAAATTCCACCAGGCTGTCAGCTGACCTC
  TTTTGCCTGCTGCTGTGAAGGTATAGCACCACCCCAGGTCCTCCTGCAGTGCGGCATCCC
  CTTGGCAGCTGCCGTCAGCCAGGCCAGCCCCAGGGAGCTTAAAACAGACATTCCACAGGG
  CCTGGGCCCCTGGGAGGTGAGGTGTGGTGTGCGGCTTCACCCAGGGCAGAACAAGGCAGA
  ATCGCAGGAAACCCGCTTCCCCTTCCTGACAGCTCCTGCCAAGCCAAATGTGCTTCCTGC
  AGCTCACGCCCACCAGCTACTGAAGGGACCCAAGGCACCCCCTGAAGCCAGCGATAGAGG
  GTCCCTCTCTGCTCCCCAGCAGCTCCTGCCCCCAAGGCCTGACTGTATATACTGTCAATG
  AAACTTTGTTTGGGTCAAGCTTCCTTCTTTCTACCCCCCAGACTTTGGCCTCTGAGTGAA
  ATGTCTCTCTTTGCCCTGTGGGGCTTCTCTCCTTGATGCTTCTTTCTTTTTTTAAAGACA
  ACCTGCCATTACCACATGACTCAATAAACCATTGCTCTTCAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003466 unedited
  NNAATAGCCGTACAGAATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAG
  GCTTCAGAAGGAGAGAGACACCGGGCCCAGGGCACCCTCGCGGGCGGACCCAAGCAGTGA
  GGGCCTGCAGCCGGCCGGCCAGGGCAGCGGCAGGCGCGGCCCGGACCTACGGGAGGAAGC
  CCCGAGCCCTCGGCGGGCTGCGAGCGACTCCCCGGCGATGCCTCACAACTCCATCAGATC
  TGGCCATGGAGGGCTGAACCAGCTGGGAGGGGCCTTTGTGAATGGCAGACCTCTGCCGGA
  AGTGGTCCGCCAGCGCATCGTAGACCTGGCCCACCAGGGTGTAAGGCCCTGCGACATCTC
  TCGCCAGCTCCGCGTCAGCCATGGCTGCGTCAGCAAGATCCTTGGCAGGTACTACGAGAC
  TGGCAGCATCCGGCCTGGAGTGATAGGGGGCTCCAAGCCCAAGGTGGCCACCCCCAAGGT
  GGTGGAGAAGATTGGGGACTACAAACGCCAGAACCCTACCATGTTTGCCTGGGAGATCCG
  AGACCGGCTCCTGGCTGAGGGCGTCTGTGACAATGACACTGTGCCCAGTGTCAGATCCAT
  TAATAGAATCATCCGGACCAAAGTGCAGCAACCATTCAACCTCCCTATGGACAGCTGCGT
  GGCCACCAAGTCCCTGAGTCCCGGACACACGCTGATCCCCAGCTCAGCTGTAACTCCCCC
  CGGAGTCACCCCAGTTCGGATTCCCCTGGGCTCCACCTACTTCATCAATGGGCTCCTGGG
  CATCGCTCAACCTGGGCAGCGCAAGAGGAAAAGGTTGACAGTGGTCAGGATAACTGCCCA
  TAAACATTGGCTTCCAGAACAGCAGCAACGGACCCCGAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_003466
• Insert Size: 2698 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003466.2, NP_003457.1
• RefSeq Size: 2707 bp
• RefSeq ORF: 1353 bp
• Locus ID: 7849
• UniProt ID: Q06710
• Cytogenetics: 2q14.1
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Thyroid cancer
• Gene Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
  Transcript Variant: This variant (PAX8A) represents the longest transcript and encodes the longest isoform (PAX8A).