IFNAR2 (NM_000874) Human Untagged Clone

CAT#: SC119622

IFNAR2 (untagged)-Human interferon (alpha, beta and omega) receptor 2 (IFNAR2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IFNAR2
• Synonyms: IFN-alpha-REC; IFN-R; IFNABR; IFNARB; IMD45
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119622 sequence for NM_000874 edited (data generated by NextGen Sequencing)
  ATGCTTTTGAGCCAGAATGCCTTCATCTTCAGATCACTTAATTTGGTTCTCATGGTGTAT
  ATCAGCCTCGTGTTTGGTATTTCATATGATTCGCCTGATTACACAGATGAATCTTGCACT
  TTCAAGATATCATTGCGAAATTTCCGGTCCATCTTATCATGGGAATTAAAAAACCACTCC
  ATTGTACCAACTCACTATACATTGCTGTATACAATCATGAGTAAACCAGAAGATTTGAAG
  GTGGTTAAGAACTGTGCAAATACCACAAGATCATTTTGTGACCTCACAGATGAGTGGAGA
  AGCACACACGAGGCCTATGTCACCGTCCTAGAAGGATTCAGCGGGAACACAACGTTGTTC
  AGTTGCTCACACAATTTCTGGCTGGCCATAGACATGTCTTTTGAACCACCAGAGTTTGAG
  ATTGTTGGTTTTACCAACCACATTAATGTGATGGTGAAATTTCCATCTATTGTTGAGGAA
  GAATTACAGTTTGATTTATCTCTCGTCATTGAAGAACAGTCAGAGGGAATTGTTAAGAAG
  CATAAACCCGAAATAAAAGGAAACATGAGTGGAAATTTCACCTATATCATTGACAAGTTA
  ATTCCAAACACGAACTACTGTGTATCTGTTTATTTAGAGCACAGTGATGAGCAAGCAGTA
  ATAAAGTCTCCCTTAAAATGCACCCTCCTTCCACCTGGCCAGGAATCAGAATCAGCAGAA
  TCTGCCAAAATAGGAGGAATAATTACTGTGTTTTTGATAGCATTGGTCTTGACAAGCACC
  ATAGTGACACTGAAATGGATTGGTTATATATGCTTAAGAAATAGCCTCCCCAAAGTCTTG
  AGGCAAGGTCTCGCTAAGGGCTGGAATGCAGTGGCTATTCACAGGTGCAGTCATAATGCA
  CTACAGTCTGAAACTCCTGAGCTCAAACAGTCGTCCTGCCTAAGCTTCCCCAGTAGCTGG
  GATTACAAGCGTGCATCCCTGTGCCCCAGTGATTAA
  
  Clone variation with respect to NM_000874.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000874 unedited
  NCCGGTCAAATTTTGTATACGACTCACTATAGGCGGCCGCGAATCGGCACCAGCGGCGGG
  TAGGAATCCCGCCGGCGAGCCGAAAGTTCCCCGAGCGCAGCCCGCGGACCACCACCCGGC
  CGCACGGGCCGCTTTTGTCCCCCGCCCGCCGCTTCTGTCCGAGAGGCCGCCCGCGAGGCG
  CATCCTGACCGCGAGCGTCGGGTCCCAGAGCCGGGCGCGGCTGGGGCCCGAGGCTAGCAT
  CTCTCGGGAGCCGCAAGGCGAGAGCTGCAAAGATGTAAAAGTCAAGAGAAGACTCTAAAA
  ATAGCAAAGATGCTTTTGAGCCAGAATGCCTTCATCTTCAGATCACTTAATTTGGTTCTC
  ATGGTGTATATCAGCCTCGTGTTTGGTATTTCATATGATTCGCCTGATTACACAGATGAA
  TCTTGCACTTTCAAGATATCATTGCGAAATTTCCGGTCCATCTTATCATGGGAATTAAAA
  AACCACTCCATTGTACCAACTCACTATACATTGCTGTATACAATCATGAGTAAACCAGAA
  GATTTGAAGGTGGTTAAGAACTGTGCAAATACCACAAGATCATTTTGTGACCTCACAGAT
  GAGTGGAGAAGCACACACGAGGCCTATGTCACCGTCCTAGAAGGATTCAGCGGGAACACA
  ACGTTGTTCAGTTGCTCACACAATTTCTGGCTGGCCATAGACATGTCTTTTGAACCACCA
  GAGTTTGAGATTGTTGGTTCTACCAACCACATTAATGTGATGGTGAAATTTCCATCTATT
  GTTGAGGAAGATTACAGTNTGATTTATCTCTCGTCATTGAAGACAGTCAGAGGNAATTGT
  TAGAAGCATNAACCCGAATANAGGANACATGAGTGGAAATTTACCTATTCATTGACAGNT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000874 unedited
  TTTTTTTTTTTTTTTTTCAGCTGTACTGTTTGCTCTTTATTTTCTACATAATAAAACTTA
  ATCACTGGGGCACAGGGATGCACGCTTGTAATCCCAGCTACTGGGGAAGCTTAGGCAGGA
  CGACTGTTTGAGCTCAGGAGTTTCAGACTGTAGTGCATTATGACTGCACCTGTGAATAGC
  CACTGCATTCCAGCCCTTAGCGAGACCTTGCCTCAAGACTTTGGGGAGGCTATTTCTTAA
  GCATATATAACCAATCCATTTCAGTGTCACTATGGTGCTTGTCAAGACCAATGCTATCAA
  AAACACAGTAATTATTCCTCCTATTTTGGCAGATTCTGCTGATTCTGATTCCTGGCCAGG
  TGGAAGGAGGGTGCATTTTAAGGGAGACTTTATTACTGCTTGCTCATCACTGTGCTCTAA
  ATAAACAGATACACAGTAGTTCGTGTTTGGAATTAACTTGTCAATGATATAGGTGAAATT
  TCCACTCATGTTTCCTTTTATTTCGGGTTTATGCTTCTTAACAATTCCCTCTGACTGTTC
  TTCNATGACGAGAGATAAATCAAACTGTAATTCTTCCTCAACAATAGATGGGAATTTCAC
  CATCACATTAATGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000874
• Insert Size: 1290 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000874.3, NP_000865.2
• RefSeq Size: 1428 bp
• RefSeq ORF: 996 bp
• Locus ID: 3455
• UniProt ID: P48551
• Cytogenetics: 21q22.11
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
  Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.