Integrin alpha 5 (ITGA5) (NM_002205) Human Untagged Clone

CAT#: SC118748

ITGA5 (untagged)-Human integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Integrin alpha 5
• Synonyms: CD49e; FNRA; VLA-5; VLA5A
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002205 edited
  GAATTCGGCACGAGGGCGGCTCCGGGTCGGTGGCCCCAGGACAGGGAAGAGCGGGCGCTA
  TGGGGAGCCGGACGCCAGAGTCCCCTCTCCACGCCGTGCAGCTGCGCTGGGGCCCCCGGC
  GCCGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGG
  GCTTCAACTTAGACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCG
  GATTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCAC
  CCAAGGCTAATACCAGCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTT
  GGGGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCC
  TGGAGTCCTCACTGTCCAGCTCAGAGGGAGAGGAGCCTGTGGAGTACAAGTCCTTGCAGT
  GGTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCACTGTACA
  GCTGGCGCACAGAGAAGGAGCCACTGAGCGACCCCGTGGGCACCTGCTACCTCTCCACAG
  ATAACTTCACCCGAATTCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAG
  GACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTT
  TAGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGA
  TTGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTC
  GCCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAAT
  TCAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACG
  GCTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAAC
  AGATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGG
  ATGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGG
  AGGTGGGCAGGGTCTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCCCACCC
  TTACCCTCACTGGCCATGATGAGTTTGGCCGATTTGGCAGCTCCTTGACCCCCCTGGGGG
  ACCTGGACCAGGATGGCTACAATGATGTGGCCATCGGGGCTCCCTTTGGTGGGGAGACCC
  AGCAGGGAGTAGTGTTTGTATTTCCTGGGGGCCCAGGAGGGCTGGGCTCTAAGCCTTCCC
  AGGTTCTGCAGCCCCTGTGGGCAGCCAGCCACACCCCAGACTTCTTTGGCTCTGCCCTTC
  GAGGAGGCCGAGACCTGGATGGCAATGGATATCCTGATCTGATTGTGGGGTCCTTTGGTG
  TGGACAAGGCTGTGGTATACAGGGGCCGCCCCATCGTGTCCGCTAGTGCCTCCCTCACCA
  TCTTCCCCGCCATGTTCAACCCAGAGGAGCGGAGCTGCAGCTTAGAGGGGAACCCTGTGG
  CCTGCATCAACCTTAGCTTCTGCCTCAATGCTTCTGGAAAACACGTTGCTGACTCCATTG
  GTTTCACAGTGGAACTTCAGCTGGACTGGCAGAAGCAGAAGGGAGGGGTACGGCGGGCAC
  TGTTCCTGGCCTCCAGGCAGGCAACCCTGACCCAGACCCTGCTCATCCAGAATGGGGCTC
  GAGAGGATTGCAGAGAGATGAAGATCTACCTCAGGAACGAGTCAGAATTTCGAGACAAAC
  TCTCGCCGATTCACATCGCTCTCAACTTCTCCTTGGACCCCCAAGCCCCAGTGGACAGCC
  ACGGCCTCAGGCCAGCCCTACATTATCAGAGCAAGAGCCGGATAGAGGACAAGGCTCAGA
  TCTTGCTGGACTGTGGAGAAGACAACATCTGTGTGCCTGACCTGCAGCTGGAAGTGTTTG
  GGGAGCAGAACCATGTGTACCTGGGTGACAAGAATGCCCTGAACCTCACTTTCCATGCCC
  AGAATGTGGGTGAGGGTGGCGCCTATGAGGCTGAGCTTCGGGTCACCGCCCCTCCAGAGG
  CTGAGTACTCAGGACTCGTCAGACACCCAGGGAACTTCTCCAGCCTGAGCTGTGACTACT
  TTGCCGTGAACCAGAGCCGCCTGCTGGTGTGTGACCTGGGCAACCCCATGAAGGCAGGAG
  CCAGTCTGTGGGGTGGCCTTCGGTTTACAGTCCCTCATCTCCGGGACACTAAGAAAACCA
  TCCAGTTTGACTTCCAGATCCTCAGCAAGAATCTCAACAACTCGCAAAGCGACGTGGTTT
  CCTTTCGGCTCTCCGTGGAGGCTCAGGCCCAGGTCACCCTGAACGGTGTCTCCAAGCCTG
  AGGCAGTGCTATTCCCAGTAAGCGACTGGCATCCCCGAGACCAGCCTCAGAAGGAGGAGG
  ACCTGGGACCTGCTGTCCACCATGTCTATGAGCTCATCAACCAAGGCCCCAGCTCCATTA
  GCCAGGGTGTGCTGGAACTCAGCTGTCCCCAGGCTCTGGAAGGTCAGCAGCTCCTATATG
  TGACCAGAGTTACGGGACTCAACTGCACCACCAATCACCCCATTAACCCAAAGGGCCTGG
  AGTTGGATCCCGAGGGTTCCCTGCACCACCAGCAAAAACGGGAAGCTCCAAGCCGCAGCT
  CTGCTTCCTCGGGACCTCAGATCCTGAAATGCCCGGAGGCTGAGTGTTTCAGGCTGCGCT
  GTGAGCTCGGGCCCCTGCACCAACAAGAGAGCCAAAGTCTGCAGTTGCATTTCCGAGTCT
  GGGCCAAGACTTTCTTGCAGCGGGAGCACCAGCCATTTAGCCTGCAGTGTGAGGCTGTGT
  ACAAAGCCCTGAAGATGCCCTACCGAATCCTGCCTCGGCAGCTGCCCCAAAAAGAGCGTC
  AGGTGGCCACAGCTGTGCAATGGACCAAGGCAGAAGGCAGCTATGGCGTCCCACTGTGGA
  TCATCATCCTAGCCATCCTGTTTGGCCTCCTGCTCCTAGGTCTACTCATCTACATCCTCT
  ACAAGCTTGGATTCTTCAAACGCTCCCTCCCATATGGCACCGCCATGGAAAAAGCTCAGC
  TCAAGCCTCCAGCCACCTCTGATGCCTGAGTCCTCCCAATTTCAGACTCCCATTCCTGAA
  GAACCAGTCCCCCCACCCTCATTCTACTGAAAAGGAGGGGTCTGGGTACTTCTTGAAGGT
  GCTGACGGCCAGGGAGAAGCTCCTCTCCCCAGCCCAGAGACATACTTGAAGGGCCAGAGC
  CAGGGGGGTGAGGAGCTGGGGATCCCTCCCCCCCATGCACTGTGAAGGACCCTTGTTTAC
  ACATACCCTCTTCATGGATGGGGGAACTCAGATCCAGGGACAGAGGCCCCAGCCTCCCTG
  AAGCCTTTGCATTTTGGAGAGTTTCCTGAAACAACTTGGAAAGATAACTAGGAAATCCAT
  TCACAGTTCTTTGGGCCAGACATGCCACAAGGACTTCCTGTCCAGCTCCAACCTGCAAAG
  ATCTGTCCTCAGCCTTGCCAGAGATCCAAAAGAAGCCCCCAGCTAAGAACCTGGAACTTG
  GGGAGTTAAGACCTGGCAGCTCTGGACAGCCCCACCCTGGTGGGCCAACAAAGAACACTA
  ACTATGCATGGTGCCCCAGGACCAGCTCAGGACAGATGCCACACAAGGATAGATGCTGGC
  CCAGGGCCCAGAGCCCAGCTCCAAGGGAATCAGAACTCAAATGGGGCCAGATCCAGCCTG
  GGGTCTGGAGTTGATCTGGAACCCAGACTCAGAACTTGGCACCTAATCCAGXXXXXXXXX
  XXXXXXXXXXXXATCTGGACCTCAGCCTGGCCAGACACAGGCCCTCCCTGTTCCCCAGAG
  AAAGGGGAGCCCACTGTCCTGGGCCTGCAGAATTTGGGTTCTGCCTGCCAGCTGCACTGA
  TGCTGCCCCTCATCTCTCTGCCCAACCCTTCCCTCACCTTGGCACCAGACACCCAGGACT
  TATTTAAACTCTGTTGCAAGTGCAATAAATCTGACCCAGTGCCCCCACTGACCAGAACTA
  GAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002205 unedited
  TATATCCCCCGCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAA
  GCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG
  CGAATTCGGCACGAGGGCGGCTCCGGGTCGGTGGCCCCAGGACAGGGAAGAGCGGGCGCT
  ATGGGGAGCCGGACGCCAGAGTCCCCTCTCCACGCCGTGCAGCTGCGCTGGGGCCCCCGG
  CGCCGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGG
  GGCTTCAACTTAGACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTC
  GGATTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCA
  CCCAAGGCTAATACCAGCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCT
  TGGGGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTC
  CTGGAGTCCTCACTGTCCAGCTCAGAGGGAGAGGAGCCTGTGGAGTACAAGTCCTTGCAG
  TGGTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCACTGTAC
  AGCTGGCGCACAGAGAAGGAGCCACTGAGCGACCCCGTGGGCACCTGCTACCTCTCCACA
  GATAACTTCACCCGAATTCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCA
  GGACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTT
  TTAGGTGGACCAGAAGCTATTTCTGGCAGGCCAGATCCTGTCTGCCACTCAGACAGATGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002205 unedited
  GCCCTCTATGTACGCGGCCGCATTTTANGATCGGTTTTTTTTTTTTTTTTTTCTAGTTCT
  GGTCAGTGGGGGCACTGGGTCAGATTTATTGCACTTGCAACAGAGTTTAAATAAGTCCTG
  GGTGTCTGGTGCCAAGGTGAGGGAAGGGTTGGGCAGAGAGATGAGGGGCAGCATCAGTGC
  AGCTGGCAGGCAGAACCCAAATTCTGCAGGCCCAGGACAGTGGGCTCCCCTTTCTCTGGG
  GAACAGGGAGGGCCTGTGTCTGGCCAGGCTGAGGTTCCAGATCTGTTGCCATCATGGCCC
  CTTCAGGGTCCTGGGAAATTCCTGGCTTCTCCTAAATCAGGGTGAACTGGGCCTCCAGGA
  TCAGGTCTGGAGCAGGCCCAAATATAGTCCTGGATCTGCCTGGATTAGGTGCCAATGTCT
  GAGTCTGGGTTCCAGATCAACTCCAGACCCCAGGCTGGATCTGGCCCCATTTGAGTTCTG
  ATTCCCCTTGGAGCTGGGCTCTGGGCCCTGGGCCAGCATCTATCCTTGTGTGGCATCTGT
  CCTGAGCTGGTCCTGGGGCACCATGCATAGTTAGTGTTCTTTGTTGGCCCACCAGGGTGG
  GGCTGTCCAGAGCTGCCAGGTCTTAACTCCCCAAGTTCCAGGTTCTTAGCTGGGGGGCTT
  CTTTTTGAATCTCTGGCAAGGCTGAAGACAGATCTTTTGCAAGTTGGAGCTGGACAGGAA
  GTCCCTGTGGCATGTTTTGGCCAAAGAACTGTGAATGGGTTTCCTAGTATCTTTTCAAGT
  TGTTTCAGGAAACTCTCCAAATGCAAAGGCTTAGGGAGGCTGGGGCCTCTGCCCCTGGTC
  TGAATTCCCCCTTCCTGAAGAGGGATGTGTAAACAGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002205
• Insert Size: 4700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002205.2, NP_002196.2
• RefSeq Size: 4267 bp
• RefSeq ORF: 3150 bp
• Locus ID: 3678
• UniProt ID: P08648
• Cytogenetics: 12q13.13
• Domains: FG-GAP
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
• Gene Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]