DcR1 (TNFRSF10C) (NM_003841) Human Untagged Clone

CAT#: SC117710

TNFRSF10C (untagged)-Human tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DcR1
• Synonyms: CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003841 edited
  GAATTCGGCACGAGGAACCTCTCCACGCGCACGAACTCAGCCAACGATTTCTGATAGATT
  TTTGGGAGTTTGACCAGAGATGCAAGGGGTGAAGGAGCGCTTCCTACCGTTAGGGAACTC
  TGGGGACAGAGCGCCCCGGCCGCCTGATGGCCGAGGCAGGGTGCGACCCAGGACCCAGGA
  CGGCGTCGGGAACCATACCATGGCCCGGATCCCCAAGACCCTAAAGTTCGTCGTCGTCAT
  CGTCGCGGTCCTGCTGCCAGTCCTAGCTTACTCTGCCACCACTGCCCGGCAGGAGGAAGT
  TCCCCAGCAGACAGTGGCCCCACAGCAACAGAGGCACAGCTTCAAGGGGGAGGAGTGTCC
  AGCAGGATCTCATAGATCAGAACATACTGGAGCCTGTAACCCGTGCACAGAGGGTGTGGA
  TTACACCAACGCTTCCAACAATGAACCTTCTTGCTTCCCATGTACAGTTTGTAAATCAGA
  TCAAAAACATAAAAGTTCCTGCACCATGACCAGAGACACAGTGTGTCAGTGTAAAGAAGG
  CACCTTCCGGAATGAAAACTCCCCAGAGATGTGCCGGAAGTGTAGCAGGTGCCCTAGTGG
  GGAAGTCCAAGTCAGTAATTGTACGTCCTGGGATGATATCCAGTGTGTTGAAGAATTTGG
  TGCCAATGCCACTGTGGAAACCCCAGCTGCTGAAGAGACAATGAACACCAGCCCGGGGAC
  TCCTGCCCCAGCTGCTGAAGAGACAATGAACACCAGCCCAGGGACTCCTGCCCCAGCTGC
  TGAAGAGACAATGACCACCAGCCCGGGGACTCCTGCCCCAGCTGCTGAAGAGACAATGAC
  CACCAGCCCGGGGACTCCTGCCCCAGCTGCTGAAGAGACAATGACCACCAGCCCGGGGAC
  TCCTGCCTCTTCTCATTACCTCTCATGCACCATCGTAGGGATCATAGTTCTAATTGTGCT
  TCTGATTGTGTTTGTTTGAAAGACTTCACTGTGGAAGAAATTCCTTCCTTACCTGAAAGG
  TTCAGGTAGGCGCTGGCTGAGGGCGGGGGGCGCTGGACACTCTCTGCCCTGCCTCCCTCT
  GCTGTGTTCCCACAGACAGAAACGCCTGCCCCTGCCCCAAGTCCTGGTGTCTCCAGCCTG
  GCTCTATCTTCCTCCTTGTGATCGTCCCATCCCCACATCCCGTGCACCCCCCAGGACCCT
  GGTCTCATCAGTCCCTCTCCTGGAGCTGGGGGTCCACACATCTCCCAGCCAAGTCCAAGA
  GGGCAGGGCCAGTTCCTCCCATCTTCAGGCCCAGCCAGGCAGGGGGCAGTCGGCTCCTCA
  ACTGGGTGACAAGGGTGAGGATGAGAAGTGGTCACGGGATTTATTCAGCCTTGGTCAGAG
  CAGAACACAGAGATTTTCCGTGTGTTGGTTTTTACTCTAGTTCCCCTTCTCATCCCCCTT
  CCTCAGGGTGTCCCCTAATTGCAAGGCCCCATTCCTGTCCCCAGCCCCAGGGCTCCTTGT
  CCAGTGTCCCAGCCCCCAGCCCAGCCCTGTGCCCCACTGTCCTCTGGGAGGGAGGTGCTG
  CATGGGCCCCTCCCCACCTGCTAAGGAGACTCGTTCTCTTCCAAGTGGTGAAAGGGCCCC
  TGAGCGTGTAGACAGAGTGACTTGGTTTCTCCAGAAACTGGAAGCCTCATGGGCTGAGGA
  ACTGCCTCCCACCCACAGCAGAGCCCTGGCGGACACAATCCCTTTTCCTCATGGCTGCCC
  TGACTCTCTGAAGTGGCTTGGGGTTCTGGGCTGACTGTGGGGGACACATGGCCATCTTGA
  GCATCACACAGACCGGCGGGTCCTGCTGCAGTCCTGTCCTTCCTGTAGTCTTCACTCCAC
  AGCCTCACTCCACAGTGAGTGACCCTCACTGGACACCCTCACTCCACAGCCTGCAACCTG
  AGGATXXXXXXXXXXXXXXXXXXXXXXXXACTCCAGCCTGGGGGACAGAGCGAGACTCCA
  TCTCAAACAACACACACACACACAAAACAACCAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003841 unedited
  CCCCGCCCCGTTGNCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA
  GCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT
  TCGGCACGAGGAACCTCTCCACGCGCACGAACTCAGCCAACGATTTCTGATAGATTTTTG
  GGAGTTTGACCAGAGATGCAAGGGGTGAAGGAGCGCTTCCTACCGTTAGGGAACTCTGGG
  GACAGAGCGCCCCGGCCGCCTGATGGCCGAGGCAGGGTGCGACCCAGGACCCAGGACGGC
  GTCGGGAACCATACCATGGCCCGGATCCCCAAGACCCTAAAGTTCGTCGTCGTCATCGTC
  GCGGTCCTGCTGCCAGTCCTAGCTTACTCTGCCACCACTGCCCGGCAGGAGGAAGTTCCC
  CAGCAGACAGTGGCCCCACAGCAACAGAGGCACAGCTTCAAGGGGGAGGAGTGTCCAGCA
  GGATCTCATAGATCAGAACATACTGGAGCCTGNTACCCGTGCACAGAGGGTGTGGATTAC
  ACCAACGCTTCCAACATGAACCTTCTTGCTTCCATGTACAGTTTGTNAATCAGATCAAAA
  CATANNAGTCCTGCCCATGACCAGAGACACAGTGTGTCAGTGTAAAGAAGCACCTTCCGG
  ATGAAACTNCCANAATGTGCCGNAGTGTANNCAGTGCCTATGGGGAAGTCCAGTCAGTAA
  TGTACGTCTGGGATGTATCCAGTGTGTGAAGATTTGTGCCATGCCATGGGAAAACCCACG
  CTGAGAGACATGACACCAGCCGGGACTCTGCCCACTGCTGAAAACATGAACCCGCCAGGA
  CTCTGGCCACTGCTGAAGACATGACACCANCCGGGACTCTGCCCAGTNTGAAAACATGAC
  CCAGCCGGGGATCTGCCCACTGTGAAAAAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003841 unedited
  GGGCTAGTTTTACTAGNACCGCGCCCTTCTANGATCGATTTTTTTTTTTTTTTTTTGGTT
  GTTTTGTGTGTGTGTGTGTTGTTTGAGATGGAGTCTCGCTCTGTCCCCCAGGCTGGAGTG
  CAGTGGCGCGATCGCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGC
  CTCAGCCTCCCGAGTAGCTGGGATTACAGGCTTTCTTTTTTCTCGCCCGGCTAATTTTTT
  GGGGCGGGGGGAGACACCGGGTTTCACCGTGTTATCCCGCCAGGATCCCACTCTTGTCCC
  CTTTCGATCCCCCCATTTCCCCCTCTCAAATGCTGGAATTCCAGGCCCGGCCCCACCCCG
  CCCCGCCCTGAAAATCTTTTTCTCTCCCTTTTTCCAACTGGCCACTTCCCTTTTTCCCTC
  CCTCCTCCCACTGCCCCTCGACCCACCCTCCCCGTGACCCGTTGCACCCACATTTCCACA
  TCCTTCAGCTTCCCCATCTCCTTTTTTAAATGTAATAATTACCTTATCTCCCTCCCCACA
  CACCCCGCGTGCGTCGTCGCCTTCTTACTCCGGGGCGCCATCCTCGCACCCCGTCTATAC
  CCGATACCCTCTGGGGGCGCAGCCGCATGCCCCGCGCAAATACCCCAATAATTAGATAAA
  ACCTCGCCCGCGGCCCCCCCCCGCGGTCGCCCGCCGCGCCCCCCATCCGCGACCCGACCC
  CGCCCGCCGCCTCGTTCCCTCCCACGTGACTAACCCCCAGGCACGCCCATTCCCGACCCA
  ATACAACGCACTCGCCGCGCGGCGCGAGGTTAGCAGTATTATCGGCCCGCGCGGAGAAAC
  CCGTCTCGTAGGTGTCCAAGCCGCCCGCTTCCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003841
• Insert Size: 2800 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003841.2, NP_003832.2
• RefSeq Size: 1404 bp
• RefSeq ORF: 780 bp
• Locus ID: 8794
• UniProt ID: O14798
• Cytogenetics: 8p21.3
• Domains: TNFR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]