CTNNA2 (NM_004389) Human Untagged Clone

CAT#: SC117392

CTNNA2 (untagged)-Human catenin (cadherin-associated protein), alpha 2 (CTNNA2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CTNNA2
• Synonyms: CAP-R; CAPR; CDCBM9; CT114; CTNR
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117392 sequence for NM_004389 edited (data generated by NextGen Sequencing)
  ATGACTTCGGCAACTTCACCTATCATTCTGAAATGGGACCCCAAAAGTTTGGAAATCCGG
  ACGCTAACAGTGGAAAGGCTGTTGGAGCCACTTGTTACACAGGTGACTACACTTGTCAAC
  ACAAGCAACAAAGGCCCATCTGGTAAAAAGAAAGGGAGGTCAAAGAAAGCCCATGTACTA
  GCTGCCTCTGTAGAGCAAGCCACTCAGAATTTCCTGGAAAAGGGTGAACAGATCGCTAAG
  GAGAGTCAAGATCTCAAAGAAGAGTTGGTGGCTGCTGTAGAGGATGTGCGCAAACAAGGT
  GAGACGATGCGGATCGCCTCCTCCGAGTTTGCAGATGACCCTTGCTCGTCGGTAAAGCGC
  GGCACCATGGTACGGGCGGCAAGGGCTTTGCTCTCCGCGGTGACACGCTTACTCATCCTG
  GCGGACATGGCAGATGTCATGAGACTTTTATCCCATCTGAAAATTGTGGAAGAGGCCCTG
  GAAGCTGTCAAAAATGCTACAAATGAGCAAGACCTTGCAAACCGTTTTAAAGAGTTTGGG
  AAAGAGATGGTGAAACTTAACTATGTAGCAGCAAGAAGACAACAGGAGCTGAAGGATCCT
  CACTGTCGGGATGAGATGGCAGCCGCCCGAGGGGCTCTGAAGAAGAATGCCACAATGCTG
  TACACGGCCTCTCAAGCATTTCTCCGCCACCCAGATGTCGCCGCGACGAGAGCCAACCGA
  GATTATGTGTTCAAACAAGTCCAGGAGGCCATCGCCGGCATCTCCAATGCTGCTCAAGCT
  ACCTCGCCCACTGACGAAGCCAAGGGCCACACGGGCATCGGCGAGCTGGCTGCGGCTCTT
  AATGAGTTTGACAATAAGATTATCCTGGACCCCATGACGTTCAGCGAGGCCAGGTTCCGG
  CCGTCCCTGGAGGAGAGGCTGGAGAGCATCATCAGCGGCGCAGCGCTGATGGCCGACTCC
  TCCTGCACGCGAGACGACCGGCGCGAGAGGATCGTGGCGGAGTGCAACGCCGTGCGGCAG
  GCGCTCCAGGACCTGCTCAGCGAGTACATGAATAATACTGGAAGGAAAGAAAAAGGAGAT
  CCTCTCAACATTGCGATTGATAAGATGACTAAGAAAACAAGAGATCTAAGGAGACAGCTT
  CGGAAAGCAGTGATGGATCACATATCTGACTCTTTCCTGGAAACCAATGTTCCTTTGCTA
  GTTCTCATTGAGGCTGCAAAGAGCGGAAATGAAAAGGAAGTGAAAGAATATGCCCAAGTT
  TTCCGTGAGCATGCCAACAAACTGGTAGAGGTTGCCAATTTGGCCTGTTCCATCTCCAAC
  AATGAAGAAGGGGTGAAATTAGTTCGGATGGCAGCCACCCAGATTGACAGCCTGTGTCCC
  CAGGTCATCAATGCCGCTCTGACACTGGCTGCCCGGCCACAGAGCAAAGTTGCTCAGGAT
  AACATGGACGTCTTCAAAGACCAGTGGGAGAAGCAGGTCCGAGTGTTGACAGAGGCCGTG
  GATGACATCACCTCAGTGGATGACTTCCTCTCTGTCTCAGAAAATCACATCTTGGAGGAT
  GTGAACAAGTGTGTGATAGCCCTCCAAGAGGGCGATGTGGACACTCTGGACCGGACTGCA
  GGGGCCATCAGGGGCCGGGCAGCTCGAGTCATACACATCATCAATGCTGAGATGGAGAAC
  TATGAAGCTGGGGTTTATACTGAGAAGGTGTTGGAAGCTACAAAATTGCTTTCTGAAACA
  GTGATGCCACGCTTCGCTGAACAAGTAGAGGTTGCCATTGAAGCCCTGAGTGCCAACGTC
  CCTCAACCGTTTGAGGAGAATGAGTTCATCGATGCCTCTCGCCTGGTGTATGATGGCGTT
  CGGGACATCAGAAAGGCTGTGCTGATGATCAGGACCCCAGAAGAACTAGAGGATGATTCT
  GACTTTGAGCAGGAAGATTATGATGTGCGTAGCAGGACAAGTGTTCAGACTGAGGATGAC
  CAGCTCATTGCAGGGCAGAGCGCACGGGCCATCATGGCGCAACTACCGCAGGAGGAGAAG
  GCAAAAATAGCTGAGCAGGTGGAGATATTCCATCAAGAGAAAAGCAAGCTGGATGCAGAA
  GTGGCCAAATGGGACGACAGCGGCAATGATATCATTGTACTGGCCAAGCAGATGTGTATG
  ATCATGATGGAAATGACAGACTTCACAAGAGGCAAAGGCCCATTGAAAAATACATCTGAT
  GTCATTAATGCTGCCAAGAAAATTGCCGAAGCAGGTTCTCGAATGGACAAATTAGCTCGT
  GCTGTGGCTGATCAGTGTCCTGATTCAGCATGTAAGCAGGATTTATTAGCCTACCTTCAA
  CGAATTGCCTTGTATTGCCATCAGCTTAATATCTGCAGCAAGGTGAAGGCAGAAGTGCAG
  AATCTGGGAGGAGAGCTCATTGTGTCAGGGCTGGACAGTGCCACATCGCTTATCCAGGCA
  GCTAAAAACCTGATGAATGCTGTTGTCCTCACGGTGAAAGCATCCTATGTGGCCTCAACC
  AAATACCAGAAGGTCTATGGGACAGCAGCTGTCAACTCACCTGTTGTGTCTTGGAAGATG
  AAGGCTCCAGAGAAGAAGCCCCTTGTGAAGAGAGAAAAGCCTGAAGAATTCCAGACACGA
  GTTCGACGAGGTTCTCAGAAGAAACACATTTCGCCTGTACAGGCTTTAAGTGAATTCAAA
  GCAATGGATTCCTTCTAG
  
  Clone variation with respect to NM_004389.3
  705 t=>g;1800 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004389 unedited
  GTCAGCATTTGAAACACGACTTCACTATAGGGCGGAACGCCCATTCGGCACGAGGCCGCC
  GCCTCTCCAGTCCCTTCTGTGATTACCACCCCACCTGCTGGGAACGGGCGAGAAAGAGGA
  GGAGGCGAGAAACTCCCACCGACCCACAGAGGGAGCATGACTTCGGCAACTTCACCCATC
  ATTCTGAAATGGGACCCCAAAAGTTTGGAAATCCGGACGCTAACAGTGGAAAGGCTGTTG
  GAGCCACTTGTTACACAGGTGACTACACTTGTCAACACAAGCAACAAAGGCCCATCTGGT
  AAAAAGAAAGGGAGGTCAAAGAAAGCCCATGTACTAGCTGCCTCTGTAGAGCAAGCCACT
  CAGAATTTCCTGGAAAAGGGTGAACAGATCGCTAAGGAGAGTCAAGATCTCAAAGAAGAG
  TTGGTGGCTGCTGTAGAGGATGTGCGCAAACAAGGTGAGACGATGCGGATCGCCTCCTCC
  GAGTTTGCAGATGACCCTTGCTCGTCGGTAAAGCGCGGCACCATGGTACGGGCGGCAAGG
  GCTTTGCTCTCCCGCGGTGACACGCTTACTCATCCTGGCGGACATGGCAGATGTCATGAG
  ACTTTTATCCCATCTGAAAATTGTTGGAAGAGGCCCTGGAAGCTGTCAAAAATGCTACAA
  ATGAGCAAGACCTTGCAAACCGTTCTAAAGAAGTTCGNNGAAAGCAGATGGNTGAAACCT
  TACCTATGTAGCAGCCACGAAGACAACAGGAGCCTGAAGGATCCCTCACTGTNCGGGAAT
  GAGAATGCCAGCCGCCCCGAGGGGCTCTGAAAAAAGAAAGCCACATTGCTGTACACGGCC
  TCTCAAGCATTTCTCCGCCCCCCAAATGTCGCCCGCGACGAGAGCCACCCGAGAATTTAT
  TGGTTCAACCAAGTTCCGGAGGCCCTCGCCGGCTTCTCAAATGCTTGTTCAGCTACCTCG
  CCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004389 unedited
  GGGGGGGGCCCCCCCGCNCCCCACAAAAAGATTTTTTTGCTGTGTCTTTCTTGTGTTAGT
  TGTGAATCAATGGTTATTAGCAACCAGCACTCCAAGCTACACCTATGTATTTGCCTCTAA
  CTTTCACACGTTGTCAGTTTCCTTCCCTCTAATATTCCACCACTGGGCCTTCTATTCCTA
  GCAAAATCATGGTTCAAATTAAAAAAGAAAAAAAAATGAAAGCAAGATTGGTCACCGTAT
  TGTGCTTCCAGTGCCCCCAGAAGGATTTTAATTGTCTCAAATATATGTTTATTGTTTTCA
  TTAAAGGGGGGAAAAAAACATTATCACTAGTAATGGCACAACTAGAAGAGGAAACAGAAT
  GCACATTAAAACAAGCATTTTAGGCTGGACTAGTTAATTTCCCCTCAGTTAAAAATCGAC
  ATAATATCACGGATATACACTTCAAGGTTAAATTGTTCAATCCATGGGCCACACACTTAA
  GCGTATTGCCTACCCCATTCCTGCACTGAAACAGAGCTATCCAAGCTTTATGTTTCACCA
  TTACACTTCCAGATTCCTCACTTATGCATATACCTGCCAATCTAATGACTCCTGCATGCA
  TTAATATATGCCTTCGTCGAGTTAATGATTATCTCCGAACCCTCCCACTTCATATTTTTT
  GCCCTCATGCAAACTCCGATGCCAACCCTCAAGAAAATGTCCCCAAAGGACCCATTTTGT
  GCTATCCTTAATAACAAGAAATCGTCTCTGGATTCCTCTTCCCCCACTTTACAGATTGGC
  CCACGCTCTCCCTCTATCCCTTCTTTCCTATCACCATTTCTTCACCCCTACTGTTTACCT
  TCAATTCTCCTCCTTGCCCCACAGGATTCACGTATTATGAACAGTTTTTCTTCCTCTTCA
  CGGCTCCTCCCTTATCACTAACCACACCATTCATCCTGATTCATACTTTTTTTTCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004389
• Insert Size: 4110 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004389.2, NP_004380.2
• RefSeq Size: 3853 bp
• RefSeq ORF: 2718 bp
• Locus ID: 1496
• UniProt ID: P26232
• Cytogenetics: 2p12
• Domains: Vinculin
• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Endometrial cancer, Leukocyte transendothelial migration, Pathways in cancer, Tight junction
• Gene Summary: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) lacks an in-frame exon in the 3' coding region compared to variant 3. The resulting isoform (1) lacks an internal segment near the C-terminus compared to isoform 3. CCDS Note: The coding region has been updated to remove a 3-nt insert (encoding Ser-310) that was present in the NCBI Build 36 reference genome assembly. This insert has been removed in the GRCh37 reference genome, and its absence is supported by transcript data.