beta 2 Adrenergic Receptor (ADRB2) (NM_000024) Human Untagged Clone

CAT#: SC116997

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ADRB2 (untagged)-Human adrenergic, beta-2-, receptor, surface (ADRB2)



  "NM_000024" in other vectors (6)

USD 310.00


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Size
    • 10 ug


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Specifications

Product Data
Product Name beta 2 Adrenergic Receptor (ADRB2) (NM_000024) Human Untagged Clone
Type Human Untagged Clone
Tag Tag Free
Symbol ADRB2
Synonyms ADRB2R; ADRBR; B2AR; BAR; BETA2AR
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Cell Selection None
Sequence Data
>OriGene sequence for NM_000024 edited
GAATTCGGCACGAGGCAGGCACCGCGAGCCCCTAGCACCCGACAAGCTGAGTGTGCAGGA
CGAGTCCCCACCACACCCACACCACAGCCGCTGAATGAGGCTTCCAGGCGTCCGCTCGCG
GCCCGCAGAGCCCCGCCGTGGGTCCGCCTGCTGAGGCGCCCCCAGCCAGTGCGCTTACCT
GCCAGACTGCGCGCCATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAAT
GGAAGCCATGCGCCGGACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGC
ATGGGCATCGTCATGTCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATC
ACAGCCATTGCCAAGTTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTG
GCCTGTGCTGATCTGGTCATGGGCCTAGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTT
ATGAAAATGTGGACTTTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTG
TGCGTCACGGCCAGCATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATT
ACTTCACCTTTCAAGTACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTG
ATGGTGTGGATTGTGTCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACAGG
GCCACCCACCAGGAAGCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACG
AACCAAGCCTATGCCATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATG
GTCTTCGTCTACTCCAGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAA
TCTGAGGGCCGCTTCCATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGG
CATGGACTCCGCAGATCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTA
GGCATCATCATGGGCACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTG
CATGTGATCCAGGATAACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGC
TATGTCAATTCTGGTTTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCC
TTCCAGGAGCTTCTGTGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGCAATGGCTACTCC
AGCAACGGCAACACAGGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAA
CTGCTGTGTGAAGACCTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCT
AGCGATAACATTGATTCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTATAAAGC
AGTTTTTCTACTTTTAAAGACCCCCCCCCGCCCAACAGAACACTAAACAGACTATTTAAC
TTGAGGGTAATAAACTTAGAATAAAATTGTAAAATTGTATAGAGATATGCAGAAGGAAGG
GCATCCTTCTGCCTTTTTTATTTTTTTAAGCTGTAAAAAGAGAGAAAACTTATTTGAGTG
ATTATTTGTTATTTGTACAGTTCAGTTCCTCTTTGCATGGAATTTGTAAGTTTATGTCTA
AAGAGCTTTAGTCCTAGAGGACCTGAGTCTGCTATATTTTCATGACTTTTCCATGTATCT
ACCTCACTATTCAAGTATTAGGGGTAATATATTGCTGCTGGTAATTTGTATCTGAAGGAG
ATTTTCCTTCCTACACCCTTGGACTTGAGGATTTTGAGTATCTCGGACCTTTCAGCTGTG
AACATGGACTCTTCCCCCACTCCTCTTATTTGCTCACACGGGGTATTTTAGGCAGGGATT
TGAGGAGCAGCTTCAGTTGTTTTCCCGAGCAAAGTXXXXXXXXXXXXXXXAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAACTCGAC
>OriGene 5' read for NM_000024 unedited
GCGGTCGAGATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGCAGGCAC
CGCGAGCCCCTAGCACCCGACAAGCTGAGTGTGCAGGACGAGTCCCCACCACACCCACAC
CACAGCCGCTGAATGAGGCTTCCAGGCGTCCGCTCGCGGCCCGCAGAGCCCCGCCGTGGG
TCCGCCTGCTGAGGCGCCCCCAGCCAGTGCGCTTACCTGCCAGACTGCGCGCCATGGGGC
AACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATGGAAGCCATGCGCCGGACCACG
ACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATGTCTCTCA
TCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAGTTCGAGC
GTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTGGTCATGG
GCCTAGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACTTTTGGCA
ACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGCATTGAGA
CCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAGTACCAGA
GCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTGTCAGGCC
TTACCTCCTTCTTGCCCATTCAGATGCACTGGTACAGGGCCACCCACCAGGAAGCCATCA
ACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCCATTGCCT
CTTCCATCGTGTCCTTCTACGTTCCCCCTGGTGATCATGGTNCTTCGTCTACTCCAGGGT
C
>OriGene 3' read for NM_000024 unedited
ACCTTCAGACATCTTATTACTGTAAACTTTATACTTTGCTCGGGAAACAACTGAAGCTGC
TCCTCAAATCCCTGCCTAAAATACCCCGTGTGAGCAAATAAGAGGAGTGGGGGAAGAGTC
CATGTTCACAGCTGAAAGGTCCGAGATACTCAAAATCCTCAAGTCCAAGGGTGTAGGAAG
GAAAATCTCCTTCAGATACAAATTACCAGCAGCAATATATTACCCCTAATACTTGAATAG
TGAGGTAGATACATGGAAAAGTCATGAAAATATAGCAGACTCAGGTCCTCTAGGACTAAA
GCTCTTTAGACATAAACTTACAAATTCCATGCAAAGAGGAACTGAACTGTACAAATAACA
AATAATCACTCAAATAAGTTTTCTCTCTTTTTACAGCTTAAAAAAATAAAAAAGGCAGAA
GGATGCCCTTCCTTCTGCATATCTCTATACAATTTTACAATTTTATTCTAAGTTTATTAC
CCTCAAGTTAAATAGTCTGTTTAGTGTTCTGTTGGGCGGGGGGGGGTCTTTAAAAGTAGA
AAAACTGCTTTATAGCAGTGAGTCATTTGTACTACAATTCCTCCCTTGTGAATCAATGTT
ATCGCTAGGCACAGTACCTTGATGGCCCACAAAGTCTTCCGTGCCTGGGAAGTCTTCACA
CAGCAGTTTATTTTCTTTCTCCTGTTCCACGTGATATCCACTCTGCTCCCCTGTGTTGCC
GTTGCTGGAGTAGCCATTGCCATANGCCTTCAAAGAGACCTGCGCAGCACAGAAGCTCCT
GGAAGGCATCCTNGAATCTGGGCTCCNGCAGTAGATAAGGGGATTGAAACCAGAATTGAC
ATAGCCTATCCAATTGAGAAGATGTAAACTTCCNTACGATGANGTATCCTGGATCAATGC
ACATGTAACGATGAAGAAGGCAA
Restriction Sites NotI-NotI     
Tag Tag Free
ACCN NM_000024
Insert Size 2050 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000024.3, NP_000015.1
RefSeq Size 2015 bp
RefSeq ORF 1242 bp
Locus ID 154
Cytogenetics 5q32
Domains 7tm_1
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Calcium signaling pathway, Endocytosis, Neuroactive ligand-receptor interaction
Gene Summary This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

Citations (6)

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